The Genomics of Aging at the Single-Cell Scale.

IF 7.9 2区 生物学 Q1 GENETICS & HEREDITY
Wei Zhou, Junyue Cao
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引用次数: 0

Abstract

Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellular changes that contribute to disrupted system homeostasis and increased vulnerability to age-related diseases. Despite the abundance of data generated over the past decade, a systematic understanding of how aging affects cell type-specific populations across the entire mammalian organism remains lacking-a critical gap for elucidating the cellular foundations of aging-related system dysfunction. In this review, we address this knowledge gap by summarizing recent single-cell studies examining the impact of aging on cell type-specific population changes across mammalian organs. We also review the impact of gender and anti-aging interventions on cell population dynamics in aged mammals. This work provides a comprehensive catalog of cellular states susceptible to aging, highlighting potential therapeutic targets for aging and age-related diseases.

单细胞尺度上的衰老基因组学。
衰老是许多疾病的主要危险因素,包括神经退行性疾病、心血管疾病和癌症。单细胞测序技术的快速发展为研究与衰老相关的细胞变化开辟了有希望的途径,这些变化有助于破坏系统稳态和增加对年龄相关疾病的易感性。尽管在过去的十年中产生了丰富的数据,但对衰老如何影响整个哺乳动物有机体中细胞类型特异性群体的系统理解仍然缺乏——这是阐明衰老相关系统功能障碍的细胞基础的关键空白。在这篇综述中,我们通过总结最近的单细胞研究来解决这一知识差距,研究衰老对哺乳动物器官中细胞类型特异性种群变化的影响。我们还回顾了性别和抗衰老干预对老年哺乳动物细胞种群动态的影响。这项工作提供了对衰老敏感的细胞状态的全面目录,突出了衰老和年龄相关疾病的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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