{"title":"The Genomics of Aging at the Single-Cell Scale.","authors":"Wei Zhou, Junyue Cao","doi":"10.1146/annurev-genom-120523-024422","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellular changes that contribute to disrupted system homeostasis and increased vulnerability to age-related diseases. Despite the abundance of data generated over the past decade, a systematic understanding of how aging affects cell type-specific populations across the entire mammalian organism remains lacking-a critical gap for elucidating the cellular foundations of aging-related system dysfunction. In this review, we address this knowledge gap by summarizing recent single-cell studies examining the impact of aging on cell type-specific population changes across mammalian organs. We also review the impact of gender and anti-aging interventions on cell population dynamics in aged mammals. This work provides a comprehensive catalog of cellular states susceptible to aging, highlighting potential therapeutic targets for aging and age-related diseases.</p>","PeriodicalId":8231,"journal":{"name":"Annual review of genomics and human genetics","volume":" ","pages":""},"PeriodicalIF":7.9000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of genomics and human genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-genom-120523-024422","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Aging is the primary risk factor for many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. The rapid advancement of single-cell sequencing technologies has opened promising avenues for investigating aging-associated cellular changes that contribute to disrupted system homeostasis and increased vulnerability to age-related diseases. Despite the abundance of data generated over the past decade, a systematic understanding of how aging affects cell type-specific populations across the entire mammalian organism remains lacking-a critical gap for elucidating the cellular foundations of aging-related system dysfunction. In this review, we address this knowledge gap by summarizing recent single-cell studies examining the impact of aging on cell type-specific population changes across mammalian organs. We also review the impact of gender and anti-aging interventions on cell population dynamics in aged mammals. This work provides a comprehensive catalog of cellular states susceptible to aging, highlighting potential therapeutic targets for aging and age-related diseases.
期刊介绍:
Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.