Central blood volume and cardiac output index predict all-cause and cardiovascular mortality in chronic hemodialysis patients.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2025-05-13 DOI:10.5414/CN111484

Chung-Kuan Wu, Li-Juan Lin, Chew-Teng Kor, Chia Lin Wu

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Abstract

Background: This study investigated the effect of central blood volume (CBV) and cardiac output index (COI) on the all-cause and cardiovascular mortality in chronic hemodialysis (CHD) patients.

Materials and methods: Adult CHD patients with functional arteriovenous access at the hemodialysis center of a medical center between January 1, 2003, and December 31, 2014, were recruited in this retrospective observational study. The primary and secondary endpoints were all-cause and cardiovascular mortality. Cumulative incidences of all-cause and cardiovascular mortality during the follow-up period were estimated and compared using the Kaplan-Meier method and log-rank test. Logistic regression and Cox proportional hazards models were used to calculate odds and hazard ratios.

Results: A total of 390 CHD patients were enrolled, including 34 patients with early mortality. The early mortality group had a higher CBV than the survival group. CBV and COI were independently associated with all-cause and cardiovascular mortality. Low COI (< 3 L/min/m2) and high CBV (≥ 1.25 L) independently predicted long-term all-cause and cardiovascular mortality. The highest risks of all-cause and cardiovascular mortality were observed in patients with low COI and high CBV, followed by high COI and high CBV and then low COI and low CBV. Mortality was the lowest in those with high COI and low CBV.

Conclusion: CBV and COI are important factors for predicting death in CHD patients. Those with low COI and high CBV had the worst outcomes.

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中心血容量和心输出量指数预测慢性血液透析患者的全因死亡率和心血管死亡率。

背景：本研究探讨了中心血容量（CBV）和心输出量指数（COI）对慢性血液透析（CHD）患者全因死亡率和心血管死亡率的影响。材料与方法：本回顾性观察性研究招募2003年1月1日至2014年12月31日在某医疗中心血液透析中心有动静脉通路的成年冠心病患者。主要和次要终点是全因死亡率和心血管死亡率。随访期间全因死亡率和心血管死亡率的累积发生率采用Kaplan-Meier方法和log-rank检验进行估计和比较。采用Logistic回归和Cox比例风险模型计算比值和风险比。结果：共纳入390例冠心病患者，其中早期死亡34例。早期死亡组的CBV高于存活组。CBV和COI与全因死亡率和心血管死亡率独立相关。低COI （< 3 L/min/m2）和高CBV（≥1.25 L）独立预测长期全因死亡率和心血管死亡率。低COI和高CBV患者的全因死亡率和心血管死亡率最高，其次是高COI和高CBV，然后是低COI和低CBV。高COI和低CBV的患者死亡率最低。结论：CBV和COI是预测冠心病患者死亡的重要因素。低COI和高CBV的患者预后最差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.