Association between serum uric acid levels and galectin-3 in patients with uncomplicated type 2 diabetes

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2025-04-11 DOI:10.1111/imj.70070

Funda Yildirim Borazan, Ihsan Ergun, Tuba Candar, Ali Kemal Oguz

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引用次数: 0

Abstract

Background

Serum uric acid (SUA) has been associated with an increased risk of cardiovascular disease (CVD) in both the general population and individuals with type 2 diabetes (T2DM). Identification of high-risk individuals is crucial for the primary prevention of CVD. A growing array of newly discovered biomarkers has been identified for predicting CVD. Galectin-3 (Gal-3) is linked to inflammatory and fibrotic processes and has been suggested as a biomarker in patients with heart failure.

Aims

Our aim is to investigate whether Gal-3 is a marker that may predict the risk of CVD caused by asymptomatic hyperuricemia in patients with uncomplicated T2DM.

Methods

Twenty patients (male/female: 10/10) with T2DM with high SUA levels and 20 controls (male/female: 10/10) matched for age and gender with T2DM with normal SUA levels were involved.

Results

SUA and Gal-3 levels exhibited a statistically significant correlation (r_s = 0.33, P = 0.03). Although the high SUA group had higher Gal-3 levels than the normal SUA group, the observed difference did not achieve statistical significance (mean: 18 (95% confidence interval (CI): 10.7–29)) vs 14.4 (95% CI: 10.4–30), P = 0.33)).

Conclusions

The present study is the first to show a correlation between the level of SUA and Gal-3 in patients with uncomplicated T2DM. This result suggests that Gal-3 could potentially serve as a marker to predict the risk of CVD in patients with uncomplicated T2DM with high SUA levels.

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无并发症2型糖尿病患者血清尿酸水平与半乳糖凝集素-3的关系

背景：血清尿酸（SUA）与普通人群和2型糖尿病（T2DM）患者心血管疾病（CVD）风险增加有关。高危人群的识别对于心血管疾病的一级预防至关重要。越来越多的新发现的生物标志物已被确定用于预测心血管疾病。半乳糖凝集素-3 （Gal-3）与炎症和纤维化过程有关，已被认为是心力衰竭患者的生物标志物。目的：我们的目的是研究Gal-3是否可以预测无并发症T2DM患者无症状高尿酸血症引起CVD的风险。方法：选取20例高SUA水平T2DM患者（男/女：10/10）和20例年龄和性别匹配的正常SUA水平T2DM患者（男/女：10/10）作为对照。结果：SUA与Gal-3水平有统计学意义（rs = 0.33, P = 0.03）。虽然高SUA组的Gal-3水平高于正常SUA组，但观察到的差异没有统计学意义(平均值：18（95%可信区间（CI）： 10.7-29) vs 14.4 (95% CI: 10.4-30), P = 0.33）。结论：本研究首次显示了非并发症T2DM患者中SUA水平与Gal-3之间的相关性。这一结果表明，Gal-3可能作为预测高SUA水平的无并发症T2DM患者CVD风险的标记物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.