Evaluation of the Influence of the National Action Plan on Antimicrobial Resistance and the COVID-19 Pandemic on the Consumption of Broad-Spectrum Antimicrobial and Anti-methicillin-resistant Staphylococcus aureus Agents.

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Ryota Goto, Ryo Inose, Ryuji Koizumi, Keisuke Sawada, Masahiro Ishikane, Norio Ohmagari, Yuichi Muraki
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Abstract

Surveillance of antimicrobial consumption (AMC) is important for controlling antimicrobial resistance (AMR). In recent years, the landscape of infectious diseases has changed due to factors such as the introduction of the National Action Plan (NAP) on AMR and the coronavirus disease 2019 (COVID-19) pandemic. However, their impact on the consumption of broad-spectrum antimicrobial and anti-methicillin-resistant Staphylococcus aureus (MRSA) agents remains unexplored. This study aimed to clarify trends in the consumption of these agents up to 2021, considering the spread of NAP and the COVID-19 pandemic. We used sales data from IQVIA Japan, which were analyzed using an interrupted time-series analysis, with April 2016 (introduction of NAP) and April 2020 (first declaration of a state of emergency) as key change points. The oral broad-spectrum antimicrobial agents consumption decreased, and the spread of the NAP (p-value: 8.15 * 10-3, 95% confidence intervals (95% CI): -7.70 * 10-3 to -2.06 * 10-3) and behavioral restrictions for the COVID-19 pandemic (p value: 1.60 * 10-8, 95% CI: -0.35 to -0.17) were significantly related to this change. Conversely, there was no notable change in the consumption of anti-MRSA agents from 2013 to 2021. Thus, the introduction of NAP and the COVID-19 pandemic may have been more effective in decreasing the consumption of oral broad-spectrum antimicrobial agents. Since antibiotics are used to treat infections across multiple anatomical therapeutic chemical classifications, continuous evaluation based on treatment purposes is important.

《国家抗微生物药物耐药性行动计划》和2019冠状病毒病疫情对广谱抗菌药物和耐甲氧西林金黄色葡萄球菌药物消费的影响评价
抗菌药物用量监测对控制耐药性具有重要意义。近年来,由于《抗微生物药物耐药性国家行动计划》的出台和2019年冠状病毒病(COVID-19)大流行等因素,传染病形势发生了变化。然而,它们对广谱抗菌药物和抗甲氧西林耐药金黄色葡萄球菌(MRSA)药物消费的影响仍未探索。考虑到NAP和COVID-19大流行的传播,本研究旨在澄清到2021年这些药物的消费趋势。我们使用了IQVIA日本的销售数据,并使用中断时间序列分析对其进行了分析,并将2016年4月(引入NAP)和2020年4月(首次宣布紧急状态)作为关键变化点。口服广谱抗菌药物用量下降,NAP的传播(p值:8.15 * 10-3,95%可信区间(95% CI): -7.70 * 10-3 ~ -2.06 * 10-3)和COVID-19大流行行为限制(p值:1.60 * 10-8,95% CI: -0.35 ~ -0.17)与这一变化显著相关。相反,从2013年到2021年,抗mrsa药物的消费量没有显著变化。因此,NAP和COVID-19大流行的引入可能更有效地减少了口服广谱抗菌药物的使用。由于抗生素用于治疗多种解剖治疗化学分类的感染,基于治疗目的的持续评估是重要的。
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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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