The calcium-sensitive receptor in the pathogenesis of sepsis.

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Bin Yu, Xuelian Li, Li Yang, Cheng Han, Jun Tan, Xiaoyan Yu, Min Li, Zhe Xu, Xiongying Chen
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Abstract

Sepsis is an organ dysfunction caused by the body's dysfunctional response to infection, which is one of the most important causes of death in critically ill patients. It is characterized by high morbidity, high mortality, and high treatment costs. Currently, the treatment of sepsis relies mainly on supportive therapy, and there is a lack of targeted intervention ways. Studying the pathogenesis of sepsis and exploring new therapeutic targets are of great theoretical and clinical importance. Calcium-sensitive receptor (CaSR) is a cell membrane receptor belonging to the family of G protein-coupled receptors and is widely distributed in various tissues and organs. Research indicates that CaSR plays a role in mitigating sepsis-induced organ dysfunction, exhibiting tissue-specific protective effects in certain tissues while inducing inflammatory responses in others. Elucidating these dual effects and the underlying signaling pathways could facilitate the development of targeted therapies for sepsis-related organ damage. This review summarizes recent literature and evidence on CaSR signaling in sepsis-induced organ dysfunction. In addition, we provide an up-to-date schematic of the most important and likely molecular signaling pathways associated with CaSR in sepsis.

钙敏感受体在败血症发病机制中的作用。
脓毒症是机体对感染反应不正常而引起的器官功能障碍,是危重病人死亡的重要原因之一。它的特点是高发病率、高死亡率和高治疗费用。目前,脓毒症的治疗主要依靠支持治疗,缺乏针对性的干预方式。研究脓毒症的发病机制,探索新的治疗靶点具有重要的理论和临床意义。钙敏感受体(Calcium-sensitive receptor, CaSR)是一种细胞膜受体,属于G蛋白偶联受体家族,广泛分布于各种组织器官中。研究表明,CaSR在减轻败血症诱导的器官功能障碍中发挥作用,在某些组织中表现出组织特异性保护作用,而在其他组织中诱导炎症反应。阐明这些双重作用和潜在的信号通路可以促进败血症相关器官损伤的靶向治疗的发展。本文综述了最近关于CaSR信号在败血症诱导的器官功能障碍中的作用的文献和证据。此外,我们还提供了脓毒症中与CaSR相关的最重要和最可能的分子信号通路的最新示意图。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
4.80%
发文量
90
审稿时长
3-8 weeks
期刊介绍: Published since 1929, the Canadian Journal of Physiology and Pharmacology is a monthly journal that reports current research in all aspects of physiology, nutrition, pharmacology, and toxicology, contributed by recognized experts and scientists. It publishes symposium reviews and award lectures and occasionally dedicates entire issues or portions of issues to subjects of special interest to its international readership. The journal periodically publishes a “Made In Canada” special section that features invited review articles from internationally recognized scientists who have received some of their training in Canada.
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