Prevalence and determinant of poor treatment outcome of poisoning in Ethiopia: systematic review and meta-analysis.

IF 2.3 3区 医学 Q1 EMERGENCY MEDICINE
Gemechu Gelana Ararame, Birbirsa Sefera Senbeta, Alex Ayenew Chereka
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引用次数: 0

Abstract

Background: Acute poisoning is a medical emergency that can be caused by exposure to significant levels of any chemical and has toxic consequences that typically manifest within hours of exposure, leading to significant morbidity and mortality.

Objectives: This study aims to determine the pooled prevalence and determinant of poor treatment outcomes of poisoning in Ethiopia.

Methods: The searches were conducted in electronic databases such as PubMed, MEDLINE, EMBASE, Science Direct, Web of Science, and Google Scholar. Original studies were selected and published until the end of December 2024, addressing the prevalence and determinant of poor treatment outcomes (death and disability) among patients. Endnote X-8 reference manager software was used to collect and organize the search outcomes and remove duplicate articles. Important data were extracted from the included studies using a format prepared in Microsoft Excel and exported to STATA 17.0 software for outcome measure analyses. The Higgins I2 test statistics were used to examine heterogeneity, and a random-effects model was used to analyze the pooled prevalence and determinant of poor treatment outcomes.

Result: Eleven research articles and 10,089 poisoned patients were included in the final analysis. This study finding showed that the pooled prevalence of poor treatment outcomes among poisoned patients was 16.13% (95% CI: 9.20, 23.05). This meta-analysis study revealed that patients living in rural areas (AOR: 2.79, 95% CI: 1.44, 5.42) and delayed time to arrival (AOR = 6.15, 95%CI: 2.46, 15.34) were determinant factors of poor treatment outcome for poisoned patients in hospitals.

Conclusion and recommendation: This study findings stated that the pooled prevalence of poor treatment outcomes among patients was high. Patients living in rural areas and delayed time to arrival at health facilities were independent determinants of poor treatment outcomes.

埃塞俄比亚中毒不良治疗结果的患病率和决定因素:系统回顾和荟萃分析。
背景:急性中毒是一种医疗紧急情况,可由大量接触任何化学品引起,其毒性后果通常在接触后数小时内显现,导致大量发病率和死亡率。目的:本研究旨在确定埃塞俄比亚中毒不良治疗结果的总患病率和决定因素。方法:在PubMed、MEDLINE、EMBASE、Science Direct、Web of Science、谷歌Scholar等电子数据库中进行检索。在2024年12月底之前,选择并发表了原始研究,讨论了患者中不良治疗结果(死亡和残疾)的患病率和决定因素。使用Endnote X-8参考文献管理软件收集整理检索结果,删除重复文章。使用Microsoft Excel编制的格式从纳入的研究中提取重要数据,并导出到STATA 17.0软件进行结果测量分析。采用Higgins I2检验统计量检验异质性,采用随机效应模型分析不良治疗结果的总患病率和决定因素。结果:11篇研究论文和10089例中毒患者纳入最终分析。本研究结果显示,中毒患者中不良治疗结果的总发生率为16.13% (95% CI: 9.20, 23.05)。本meta分析研究显示,农村地区患者(AOR: 2.79, 95%CI: 1.44, 5.42)和到达时间延迟(AOR = 6.15, 95%CI: 2.46, 15.34)是中毒患者住院治疗效果不佳的决定因素。结论和建议:本研究结果表明,患者中不良治疗结果的总发生率很高。生活在农村地区的患者和到达卫生设施的时间延迟是治疗结果不佳的独立决定因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Emergency Medicine
BMC Emergency Medicine Medicine-Emergency Medicine
CiteScore
3.50
自引率
8.00%
发文量
178
审稿时长
29 weeks
期刊介绍: BMC Emergency Medicine is an open access, peer-reviewed journal that considers articles on all urgent and emergency aspects of medicine, in both practice and basic research. In addition, the journal covers aspects of disaster medicine and medicine in special locations, such as conflict areas and military medicine, together with articles concerning healthcare services in the emergency departments.
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