A Quasi-Resonant System for High-Frequency Trans-Spinal Magnetic Stimulation (HF-TSMS).

IF 4.4 2区医学 Q2 ENGINEERING, BIOMEDICAL

IEEE Transactions on Biomedical Engineering Pub Date : 2025-05-09 DOI:10.1109/TBME.2025.3568701

Francesca Marturano, Don Straney, Micol Colella, Yin-Ching Iris Chen, Ilknur Ay, Giorgio Bonmassar

{"title":"A Quasi-Resonant System for High-Frequency Trans-Spinal Magnetic Stimulation (HF-TSMS).","authors":"Francesca Marturano, Don Straney, Micol Colella, Yin-Ching Iris Chen, Ilknur Ay, Giorgio Bonmassar","doi":"10.1109/TBME.2025.3568701","DOIUrl":null,"url":null,"abstract":"Objective: We designed, developed, and tested a novel non-invasive system for high-frequency (HF) trans-spinal magnetic stimulation (TSMS).Methods: The system is based on a quasi-resonant pulse width modulation (PWM) design with customizable parameters, coupled with a custom figure-8 coil optimized for selective stimulation of spinal fibers. A key innovation is sequence-controlled zero current switching (SCZCS), which minimizes switching losses.Results: Through quasi-resonance, a capacitor bank canceled the coil inductance, enabling the generation of 10 kA current pulses with input voltages over three times lower than traditional magnetic stimulation methods. Preliminary rodent experiments, including electrophysiological recordings from the common peroneal nerve studies, demonstrated that the system's pulses reached the spinal cord. The HF-TSMS system operated safely, delivering HF stimulation without significant coil heating during experimental sessions.Conclusion: The proposed HF-TSMS system generated HF current pulses at lower cost, with reduced switching losses and higher efficiency.Significance: This system has the potential for integration into clinical practice as a safe and non-invasive treatment option for chronic pain management.","PeriodicalId":13245,"journal":{"name":"IEEE Transactions on Biomedical Engineering","volume":"PP ","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1109/TBME.2025.3568701","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: We designed, developed, and tested a novel non-invasive system for high-frequency (HF) trans-spinal magnetic stimulation (TSMS).

Methods: The system is based on a quasi-resonant pulse width modulation (PWM) design with customizable parameters, coupled with a custom figure-8 coil optimized for selective stimulation of spinal fibers. A key innovation is sequence-controlled zero current switching (SCZCS), which minimizes switching losses.

Results: Through quasi-resonance, a capacitor bank canceled the coil inductance, enabling the generation of 10 kA current pulses with input voltages over three times lower than traditional magnetic stimulation methods. Preliminary rodent experiments, including electrophysiological recordings from the common peroneal nerve studies, demonstrated that the system's pulses reached the spinal cord. The HF-TSMS system operated safely, delivering HF stimulation without significant coil heating during experimental sessions.

Conclusion: The proposed HF-TSMS system generated HF current pulses at lower cost, with reduced switching losses and higher efficiency.

Significance: This system has the potential for integration into clinical practice as a safe and non-invasive treatment option for chronic pain management.

查看原文本刊更多论文

高频经脊髓磁刺激的准共振系统。

目的：我们设计、开发并测试了一种新的无创高频（HF）经脊髓磁刺激（TSMS）系统。方法：该系统基于准谐振脉宽调制（PWM）设计，具有可定制的参数，加上定制的数字8线圈，用于选择性刺激脊髓纤维。一个关键的创新是序控零电流开关（SCZCS），它最大限度地减少了开关损耗。结果：通过准共振，电容器组消除了线圈电感，能够产生10 kA电流脉冲，输入电压比传统磁刺激方法低三倍以上。初步的啮齿动物实验，包括腓总神经研究的电生理记录，证明了该系统的脉冲到达脊髓。HF- tsms系统运行安全，在实验过程中提供高频刺激而没有明显的线圈加热。结论：所提出的高频- tsms系统产生高频电流脉冲的成本更低，开关损耗更小，效率更高。意义：该系统具有整合到临床实践的潜力，作为慢性疼痛管理的安全和非侵入性治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

IEEE Transactions on Biomedical Engineering 工程技术-工程：生物医学

CiteScore

9.40

自引率

4.30%

发文量

880

审稿时长

2.5 months

期刊介绍： IEEE Transactions on Biomedical Engineering contains basic and applied papers dealing with biomedical engineering. Papers range from engineering development in methods and techniques with biomedical applications to experimental and clinical investigations with engineering contributions.