Knowledge, attitudes, and practices of epilepsy patients regarding the ketogenic diet therapy: A cross-sectional study

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Epilepsia Open Pub Date : 2025-05-05 DOI:10.1002/epi4.70048

Xiuping Zhang, Meizhen Sun, Guofang Xue, Yongxiong Zhao, Taotao Du, Xueying Guan, Yong Xu

{"title":"Knowledge, attitudes, and practices of epilepsy patients regarding the ketogenic diet therapy: A cross-sectional study","authors":"Xiuping Zhang, Meizhen Sun, Guofang Xue, Yongxiong Zhao, Taotao Du, Xueying Guan, Yong Xu","doi":"10.1002/epi4.70048","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The therapeutic ketogenic diet is typically used in epilepsy treatments, yet there has been insufficient understanding regarding the knowledge, attitudes, and practices (KAP) of epilepsy patients concerning this dietary therapy. This study aims to investigate the KAP of epilepsy patients regarding ketogenic diet therapy, with the goal of identifying gaps in knowledge and attitudes that may impact clinical outcomes.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>A cross-sectional study was conducted between November 2023 and December 2023 at three epilepsy centers in Shanxi Province: the First Hospital of Shanxi Medical University, the Second Hospital of Shanxi Medical University, and Taiyuan Epilepsy Hospital. Data, including demographic characteristics and KAP scores, were collected via online questionnaires, yielding a total of 612 valid responses, with 320 (52.29%) males.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The mean KAP scores were calculated as follows: knowledge score 4.99 ± 6.72 (possible range: 0–24), attitude score 24.82 ± 2.34 (possible range: 8–40), and practice score 29.48 ± 8.49 (possible range: 9–45). Multivariate analysis revealed that the attitude score (OR = 1.443, 95% CI: [1.296–1.607], <i>p</i> < 0.001) and an epilepsy duration of 5–10 years (OR = 3.086, 95% CI: [1.716–5.548], <i>p</i> < 0.001) were independently associated with positive practice. Additionally, Structural Equation Modeling indicated that knowledge (<i>β</i> = 0.034, <i>p</i> = 0.012) and attitude (<i>β</i> = 0.583, <i>p</i> = 0.010) directly influenced practice, while knowledge also directly affected attitude (<i>β</i> = 0.565, <i>p</i> = 0.013), with an indirect effect on practice through attitude (<i>β</i> = 0.329, <i>p</i> = 0.009).</p>\n </section>\n \n <section>\n \n <h3> Significance</h3>\n \n <p>The study found insufficient knowledge, suboptimal attitudes, and negative practices toward the ketogenic diet among epilepsy patients. This underscores the need for targeted educational interventions to enhance patient engagement and optimize clinical outcomes.</p>\n </section>\n \n <section>\n \n <h3> Plain Language Summary</h3>\n \n <p>This study looked at how much epilepsy patients know about, feel about, and use the ketogenic diet as a treatment. We found that patients generally know little about the diet, have mixed feelings, and do not use it much. Better understanding and positive attitudes were linked to better use of the diet. The results suggest that more education could help patients use the diet more effectively, which might improve their health outcomes.</p>\n </section>\n </div>","PeriodicalId":12038,"journal":{"name":"Epilepsia Open","volume":"10 3","pages":"866-879"},"PeriodicalIF":2.8000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/epi4.70048","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epilepsia Open","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/epi4.70048","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The therapeutic ketogenic diet is typically used in epilepsy treatments, yet there has been insufficient understanding regarding the knowledge, attitudes, and practices (KAP) of epilepsy patients concerning this dietary therapy. This study aims to investigate the KAP of epilepsy patients regarding ketogenic diet therapy, with the goal of identifying gaps in knowledge and attitudes that may impact clinical outcomes.

Method

A cross-sectional study was conducted between November 2023 and December 2023 at three epilepsy centers in Shanxi Province: the First Hospital of Shanxi Medical University, the Second Hospital of Shanxi Medical University, and Taiyuan Epilepsy Hospital. Data, including demographic characteristics and KAP scores, were collected via online questionnaires, yielding a total of 612 valid responses, with 320 (52.29%) males.

Results

The mean KAP scores were calculated as follows: knowledge score 4.99 ± 6.72 (possible range: 0–24), attitude score 24.82 ± 2.34 (possible range: 8–40), and practice score 29.48 ± 8.49 (possible range: 9–45). Multivariate analysis revealed that the attitude score (OR = 1.443, 95% CI: [1.296–1.607], p < 0.001) and an epilepsy duration of 5–10 years (OR = 3.086, 95% CI: [1.716–5.548], p < 0.001) were independently associated with positive practice. Additionally, Structural Equation Modeling indicated that knowledge (β = 0.034, p = 0.012) and attitude (β = 0.583, p = 0.010) directly influenced practice, while knowledge also directly affected attitude (β = 0.565, p = 0.013), with an indirect effect on practice through attitude (β = 0.329, p = 0.009).

Significance

The study found insufficient knowledge, suboptimal attitudes, and negative practices toward the ketogenic diet among epilepsy patients. This underscores the need for targeted educational interventions to enhance patient engagement and optimize clinical outcomes.

Plain Language Summary

This study looked at how much epilepsy patients know about, feel about, and use the ketogenic diet as a treatment. We found that patients generally know little about the diet, have mixed feelings, and do not use it much. Better understanding and positive attitudes were linked to better use of the diet. The results suggest that more education could help patients use the diet more effectively, which might improve their health outcomes.

查看原文本刊更多论文

癫痫患者关于生酮饮食疗法的知识、态度和实践：一项横断面研究。

目的：治疗性生酮饮食是治疗癫痫的常用方法，但对癫痫患者对这种饮食疗法的认识、态度和实践（KAP）了解不足。本研究旨在调查癫痫患者对生酮饮食治疗的认知认知，以确定可能影响临床结果的知识和态度差距。方法：于2023年11月至2023年12月在山西省三家癫痫中心：山西医科大学第一医院、山西医科大学第二医院和太原市癫痫医院进行横断面研究。通过在线问卷收集数据，包括人口统计学特征和KAP得分，共获得612份有效回复，其中320名（52.29%）为男性。结果：KAP平均得分为：知识分4.99±6.72分（可能范围0 ~ 24），态度分24.82±2.34分（可能范围8 ~ 40），练习分29.48±8.49分（可能范围9 ~ 45）。多因素分析显示，癫痫病人的态度评分(OR = 1.443, 95% CI: [1.296-1.607]， p有显著性意义：研究发现癫痫病人对生酮饮食的认知不足、态度不佳、消极行为。这强调了有针对性的教育干预的必要性，以提高患者的参与和优化临床结果。简单的语言总结：这项研究考察了癫痫患者对生酮饮食作为一种治疗方法的了解、感受和使用程度。我们发现，患者一般对这种饮食知之甚少，感情复杂，不怎么使用。更好的理解和积极的态度与更好地利用饮食有关。结果表明，更多的教育可以帮助患者更有效地使用这种饮食，这可能会改善他们的健康状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊