Jill Dicke, Laura Hero, Saskia Kuhl, Roland Goldbrunner, Marco Timmer
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引用次数: 0
Abstract
Background/aim: Brain metastases from the most common primary sites - lung carcinoma, breast carcinoma, and melanoma - are more frequent than primary brain tumors. YAP1/TAZ are regulators of tissue growth and epithelial-mesenchymal transition (EMT) within the hippo pathway. The aim of the study was the evaluation of the role of YAP1/TAZ in brain metastasis.
Materials and methods: Expression levels of YAP1 and TAZ were measured in samples of primary and relapsed brain metastases from patients with melanoma, breast carcinoma, and bronchial carcinoma using qPCR and western blot.
Results: Expression of YAP1 and TAZ was highest in melanoma followed by bronchial carcinoma and lowest in breast carcinoma. For YAP1, expression in primary metastasis was higher than in relapsed metastasis.
Conclusion: Because of the important role of YAP1/TAZ in EMT, targeting these genes could be a promising approach to reduce the risk of metastasis.
期刊介绍：
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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