High Expression of OR1F1 Protein as a Potential Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.

IF 1.6 4区医学 Q4 ONCOLOGY

Anticancer research Pub Date : 2025-05-01 DOI:10.21873/anticanres.17575

Shunsuke Yamagishi, Mitsuro Kanda, Takahiro Shinozuka, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Haruyoshi Tanaka, Hideki Takami, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera, Yukiyasu Okamura

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引用次数: 0

Abstract

Background/aim: In patients with esophageal squamous cell carcinoma (ESCC), the identification of biomarkers that enable precise stratification of postoperative prognostic risk is crucial for developing personalized treatment strategies. Biomarker reproducibility across multiple independent cohorts is a key consideration in biomarker discovery.

Materials and methods: Transcriptome analysis was performed on primary tumor tissues from patients with ESCC who experienced recurrence in distant organs, thus identifying olfactory receptor family 1 subfamily F member 1 (OR1F1) as a candidate biomarker. OR1F1 protein expression and prognostic value were analyzed in two independent cohorts of patients with ESCC who underwent curative esophagectomy using immunohistochemical staining.

Results: In Cohort 1, high expression of OR1F1 protein in ESCC tissues was significantly correlated with reduced overall survival (OS) and disease-free survival (DFS). Multivariate analysis of OS after surgery identified high OR1F1 protein expression as an independent adverse prognostic factor. Likewise, high OR1F1 protein expression in tissues was strongly associated with reduced OS and DFS in Cohort 2. In both cohorts, patient prognosis could be stratified into three distinct risk levels based on the expression level of OR1F1 protein.

Conclusion: Tissue OR1F1 protein expression could serve as a valuable prognostic biomarker for patients with ESCC.

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OR1F1蛋白高表达作为食管鳞状细胞癌的潜在预后生物标志物

背景/目的：在食管鳞状细胞癌（ESCC）患者中，识别能够精确分层术后预后风险的生物标志物对于制定个性化治疗策略至关重要。生物标志物在多个独立队列中的可重复性是生物标志物发现的关键考虑因素。材料和方法：对远端器官复发的ESCC患者的原发肿瘤组织进行转录组分析，确定嗅觉受体家族1亚家族F成员1 （OR1F1）作为候选生物标志物。在两个独立的ESCC患者中，使用免疫组织化学染色分析OR1F1蛋白表达和预后价值。结果：在队列1中，OR1F1蛋白在ESCC组织中的高表达与总生存期（OS）和无病生存期（DFS）的降低显著相关。术后OS的多因素分析发现OR1F1蛋白高表达是一个独立的不良预后因素。同样，在队列2中，组织中OR1F1蛋白的高表达与OS和DFS的降低密切相关。在这两个队列中，根据OR1F1蛋白的表达水平，患者预后可分为三个不同的风险水平。结论：组织OR1F1蛋白表达可作为ESCC患者有价值的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anticancer research 医学-肿瘤学

CiteScore

3.70

自引率

10.00%

发文量

566

审稿时长

2 months

期刊介绍： ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed. ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies). Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.