[The pleiotropic role of MEF2C in bone tissue development and metabolism].

Q3 Medicine

生理学报 Pub Date : 2025-04-25 DOI:10.13294/j.aps.2025.0024

Hao-Jie Xiao, Rui-Qi Huang, Sheng-Jie Lin, Jin-Yang Li, Xue-Jie Yi, Hai-Ning Gao

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引用次数: 0

Abstract

The development of bone in human body and the maintenance of bone mass in adulthood are regulated by a variety of biological factors. Myocyte enhancer factor 2C (MEF2C), as one of the many factors regulating bone tissue development and balance, has been shown to play a key role in bone development and metabolism. However, there is limited systematic analysis on the effects of MEF2C on bone tissue. This article reviews the role of MEF2C in bone development and metabolism. During bone development, MEF2C promotes the development of neural crest cells (NC) into craniofacial cartilage and directly promotes cartilage hypertrophy. In terms of bone metabolism, MEF2C exhibits a differentiated regulatory model across different types of osteocytes, demonstrating both promoting and other potential regulatory effects on bone formation, with its stimulating effect on osteoclasts being determined. In view of the complex roles of MEF2C in bone tissue, this paper also discusses its effects on some bone diseases, providing valuable insights for the physiological study of bone tissue and strategies for the prevention of bone diseases.

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[MEF2C在骨组织发育和代谢中的多效作用]。

人体骨骼的发育和成人期骨量的维持受多种生物因素的调控。肌细胞增强因子2C （Myocyte enhancer factor 2C, MEF2C）是调节骨组织发育和平衡的众多因子之一，在骨骼发育和代谢中起着关键作用。然而，关于MEF2C对骨组织影响的系统分析有限。本文就MEF2C在骨发育和代谢中的作用进行综述。在骨发育过程中，MEF2C促进神经嵴细胞（neural crest cells， NC）向颅面软骨发育，并直接促进软骨肥大。在骨代谢方面，MEF2C在不同类型的骨细胞中表现出差异化的调节模式，对骨形成既有促进作用，也有其他潜在的调节作用，其对破骨细胞的刺激作用尚待确定。鉴于MEF2C在骨组织中的复杂作用，本文还讨论了其在一些骨病中的作用，为骨组织生理学研究和骨病预防策略提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.