Exosome-mediated ferroptosis in the tumor microenvironment: from molecular mechanisms to clinical application.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-05-06 DOI:10.1038/s41420-025-02484-y

Na Liu, Tianqing Wu, Guohu Han, Minbin Chen

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引用次数: 0

Abstract

Ferroptosis in the tumor microenvironment (TME) plays a crucial role in the development, metastasis, immune escape, and drug resistance of various types of cancer. A better understanding of ferroptosis in the TME could illuminate novel aspects of this process and promote the development of targeted therapies. Compelling evidence indicates that exosomes are key mediators in regulating the TME. In this respect, it is now understood that exosomes can deliver biologically functional molecules to recipient cells, influencing cancer progression by reprogramming the metabolism of cancer cells and their surrounding stromal cells through ferroptosis. In this review, we focus on the role of exosomes in the TME and describe how they contribute to tumor reprogramming, immunosuppression, and the formation of pre-metastatic niches through ferroptosis. In addition, we highlight exosome-mediated ferroptosis as a potential target for cancer therapy and discuss strategies employing exosomes in ferroptosis treatment. Finally, we outline the current applications and challenges of targeted exosome-mediated ferroptosis therapy in tumor immunotherapy and chemotherapy. Our aim is to advance research on the link between exosomes and ferroptosis in the TME, and we pose questions to guide future studies in this area.

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肿瘤微环境中外泌体介导的铁下垂：从分子机制到临床应用。

肿瘤微环境中的铁上塌（Ferroptosis in tumor microenvironment， TME）在各类癌症的发生、转移、免疫逃逸和耐药过程中起着至关重要的作用。更好地了解TME中的铁下垂可以阐明这一过程的新方面，并促进靶向治疗的发展。令人信服的证据表明外泌体是调节TME的关键介质。在这方面，现在已经了解外泌体可以将具有生物学功能的分子传递给受体细胞，通过铁凋亡重编程癌细胞及其周围基质细胞的代谢，从而影响癌症的进展。在这篇综述中，我们将重点关注外泌体在TME中的作用，并描述它们如何通过铁凋亡促进肿瘤重编程、免疫抑制和转移前生态位的形成。此外，我们强调外泌体介导的铁下垂是癌症治疗的潜在靶点，并讨论了利用外泌体治疗铁下垂的策略。最后，我们概述了靶向外泌体介导的铁下垂治疗在肿瘤免疫治疗和化疗中的应用现状和挑战。我们的目的是进一步研究外泌体与TME铁下垂之间的联系，并提出一些问题来指导该领域的未来研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.