Role and Significance of MicroRNAs in the Relationship Between Obesity and Cancer.

IF 1.9 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Balkan Medical Journal Pub Date : 2025-05-05 DOI:10.4274/balkanmedj.galenos.2025.2025-3-60

Ahmed S Doghish, Reda M Mansour, Sherif S Abdel Mageed, Hebatallah Ahmed Mohamed Moustafa, Osama A Mohammed, Ahmed E Elesawy, Nehal I Rizk

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Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that are essential for regulating gene expression at the posttranscriptional stage. Recent research shows that miRNAs are crucial in the development of two major global health issues: obesity and cancer, two significant health issues worldwide. This study examines the complex mechanisms by which miRNAs govern vital biological processes, including adipogenesis, cancer, and metabolic dysregulation. We highlight the dual function of miRNAs as oncogenes and tumor suppressors in obesity-related malignancies and investigate their potential as prognostic and diagnostic markers. To demonstrate their varied roles, specific examples of vital miRNAs are underscored, such as miR-21, which promotes adipogenesis and is overexpressed in various cancers, and miR-34a, a tumor suppressor involved in cell cycle arrest and apoptosis. In addition, we examined the recent developments in miRNA-based therapies, which include miRNA inhibitors, mimics, and novel delivery vehicles and have the potential for treating obesity-related malignancies. This review aims to clarify, within the framework of miRNA biology, the therapeutic potential of miRNAs in addressing the interrelation between obesity and cancer.

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microrna在肥胖与癌症关系中的作用和意义。

MicroRNAs （miRNAs）是一种小的非编码rna，在转录后阶段调节基因表达是必不可少的。最近的研究表明，mirna在肥胖和癌症这两大全球健康问题的发展中起着至关重要的作用。本研究探讨了mirna控制重要生物过程的复杂机制，包括脂肪生成、癌症和代谢失调。我们强调了mirna在肥胖相关恶性肿瘤中作为癌基因和肿瘤抑制因子的双重功能，并研究了它们作为预后和诊断标志物的潜力。为了证明它们的不同作用，本文强调了重要mirna的具体例子，如促进脂肪形成并在各种癌症中过表达的miR-21，以及参与细胞周期阻滞和凋亡的肿瘤抑制因子miR-34a。此外，我们研究了基于miRNA的治疗方法的最新进展，包括miRNA抑制剂、模拟物和新型递送载体，它们具有治疗肥胖相关恶性肿瘤的潜力。这篇综述的目的是在miRNA生物学的框架内阐明miRNA在解决肥胖和癌症之间的相互关系方面的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Balkan Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

4.10

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The Balkan Medical Journal (Balkan Med J) is a peer-reviewed open-access international journal that publishes interesting clinical and experimental research conducted in all fields of medicine, interesting case reports and clinical images, invited reviews, editorials, letters, comments and letters to the Editor including reports on publication and research ethics. The journal is the official scientific publication of the Trakya University Faculty of Medicine, Edirne, Turkey and is printed six times a year, in January, March, May, July, September and November. The language of the journal is English. The journal is based on independent and unbiased double-blinded peer-reviewed principles. Only unpublished papers that are not under review for publication elsewhere can be submitted. Balkan Medical Journal does not accept multiple submission and duplicate submission even though the previous one was published in a different language. The authors are responsible for the scientific content of the material to be published. The Balkan Medical Journal reserves the right to request any research materials on which the paper is based. The Balkan Medical Journal encourages and enables academicians, researchers, specialists and primary care physicians of Balkan countries to publish their valuable research in all branches of medicine. The primary aim of the journal is to publish original articles with high scientific and ethical quality and serve as a good example of medical publications in the Balkans as well as in the World.