Diet and Risk for Incident Diverticulitis in Women : A Prospective Cohort Study.

IF 19.6 1区医学 Q1 MEDICINE, GENERAL & INTERNAL

Annals of Internal Medicine Pub Date : 2025-05-06 DOI:10.7326/ANNALS-24-03353

Trevor Barlowe, Chelsea Anderson, Hazel B Nichols, Anna C Salvador, Robert S Sandler, Dale P Sandler, Anne F Peery

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引用次数: 0

Abstract

Background: Patients with diverticulitis often attempt to control their diet with a particular focus on avoiding nuts and seeds. However, whether dietary patterns or dietary intake of nuts and seeds are associated with diverticulitis risk is poorly studied, particularly in women.

Objective: To determine whether select diets affect incident diverticulitis risk in women.

Design: Prospective cohort study.

Setting: Cohort study in the United States and Puerto Rico.

Participants: Women aged 35 to 74 years at enrollment who responded to food frequency and diverticulitis questionnaires and had no history of inflammatory bowel disease, cancer, or diverticulitis (n = 29 916).

Intervention: Food frequency questionnaires were used to calculate dietary index scores and to assess intake of nuts, seeds, and corn.

Measurements: Cox proportional hazards regression was used to estimate adjusted hazard ratios (aHRs) and 95% CIs for the associations between each dietary component or dietary index and diverticulitis risk.

Results: 1531 cases of incident diverticulitis for 415 103 person-years of follow-up were identified. Intake of peanuts, nuts, and seeds (aHR,1.07 [95% CI, 0.91 to 1.25]) and fresh fruits with edible seeds (aHR,1.06 [CI, 0.90 to 1.24]) was not associated with incident diverticulitis. There was a reduced risk for incident diverticulitis in women in the highest quartile of healthy diets compared with the lowest quartile: the Dietary Approaches to Stop Hypertension diet (aHR, 0.77 [CI, 0.65 to 0.90]), the Healthy Eating Index (aHR, 0.78 [CI, 0.66 to 0.91]), the Alternative Healthy Eating Index (aHR, 0.81 [CI, 0.69 to 0.95]), and the Alternative Mediterranean diet (aHR, 0.91 [CI, 0.78 to 1.06]).

Limitation: Confounding, selection bias, and measurement bias are possible.

Conclusion: Healthy diets were associated with a reduced risk for incident diverticulitis in women. Consumption of nuts and seeds was not associated with diverticulitis risk.

Primary funding source: National Institutes of Health.

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饮食与女性发生憩室炎的风险：一项前瞻性队列研究

背景：憩室炎患者经常试图控制饮食，特别注意避免坚果和种子。然而，饮食模式或坚果和种子的饮食摄入是否与憩室炎风险相关的研究很少，特别是在女性中。目的：确定饮食选择是否影响女性发生憩室炎的风险。设计：前瞻性队列研究。背景：美国和波多黎各的队列研究。参与者：年龄在35至74岁之间的女性，她们对食物频率和憩室炎问卷有反应，没有炎症性肠病、癌症或憩室炎的病史（n = 29916）。干预：使用食物频率问卷来计算饮食指数得分，并评估坚果、种子和玉米的摄入量。测量方法：采用Cox比例风险回归来估计每种饮食成分或饮食指数与憩室炎风险之间的校正风险比（aHRs）和95% ci。结果：在415103人年的随访中发现1531例憩室炎。摄入花生、坚果和种子（aHR,1.07 [95% CI， 0.91至1.25]）和含有可食用种子的新鲜水果（aHR,1.06 [95% CI， 0.90至1.24]）与憩室炎的发生无关。与最低四分位数相比，健康饮食最高四分位数的女性发生憩室炎的风险降低：停止高血压饮食的饮食方法（aHR, 0.77 [CI， 0.65至0.90]）、健康饮食指数（aHR, 0.78 [CI， 0.66至0.91]）、替代健康饮食指数（aHR, 0.81 [CI， 0.69至0.95]）和替代地中海饮食（aHR, 0.91 [CI， 0.78至1.06]）。局限性：可能存在混淆、选择偏倚和测量偏倚。结论：健康饮食与降低女性憩室炎发生风险相关。食用坚果和种子与憩室炎风险无关。主要资金来源：美国国立卫生研究院。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Internal Medicine 医学-医学：内科

CiteScore

23.90

自引率

1.80%

发文量

1136

审稿时长

3-8 weeks

期刊介绍： Established in 1927 by the American College of Physicians (ACP), Annals of Internal Medicine is the premier internal medicine journal. Annals of Internal Medicine’s mission is to promote excellence in medicine, enable physicians and other health care professionals to be well informed members of the medical community and society, advance standards in the conduct and reporting of medical research, and contribute to improving the health of people worldwide. To achieve this mission, the journal publishes a wide variety of original research, review articles, practice guidelines, and commentary relevant to clinical practice, health care delivery, public health, health care policy, medical education, ethics, and research methodology. In addition, the journal publishes personal narratives that convey the feeling and the art of medicine.