B vitamins and colorectal cancer: exploring research hotspots and frontiers from a bibliometric and visual analysis (1994-2024).

IF 2.9 3区医学 Q2 ONCOLOGY

Carcinogenesis Pub Date : 2025-04-03 DOI:10.1093/carcin/bgaf021

Meichen Li, Lingshi Meng, Hong Gu, Yuan Tian, Boyang Qu, Yanrong Ao, Xingyang Chen, Yuan Song, Weiwei Cui

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引用次数: 0

Abstract

Most studies suggest that B vitamins can reduce the risk of colorectal cancer (CRC), and research in this field has been growing. Focusing on 2617 articles in the field, this study used CiteSpace and VOSviewer software to evaluate the contributions of various countries/regions, institutions, authors, and journals. The United States and Harvard University were identified as the most productive nation and institution, respectively, with Edward L. Giovannucci (Harvard) being the top contributor. Cancer Epidemiology Biomarkers & Prevention was recognized as the leading journal. Through the analysis of keywords and citations, we found that the potential of B vitamins (B1, B2, B6, B9, and B12) in the prevention and treatment of CRC and their mechanisms including regulation of gene expression, anti-inflammatory and antioxidant, and modulation of gut microenvironment are hot topics of research in this field. Burst detection analysis further revealed that the application of nanoparticle-based targeted drug delivery systems (such as folate-conjugated nanocarriers) in the treatment of CRC represents both a current hotspot and a future trend. This study offers a comprehensive overview of the field, highlights research hotspots and trends, and offers valuable information for researchers to further grasp the research direction.

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B族维生素与结直肠癌：从文献计量学和视觉分析探索研究热点和前沿（1994-2024）。

大多数研究表明，B族维生素可以降低患结直肠癌（CRC）的风险，这一领域的研究一直在增加。本研究以该领域的2617篇论文为研究对象，利用CiteSpace和VOSviewer软件对不同国家/地区、机构、作者和期刊的贡献进行评估。美国和哈佛大学分别被评为最具生产力的国家和机构，爱德华·l·乔凡努奇（哈佛大学）是贡献最大的国家和机构。《癌症流行病学、生物标志物与预防》被公认为领先期刊。通过关键词和引文分析，我们发现B族维生素（B1、B2、B6、B9、B12）在防治结直肠癌中的潜力及其调控基因表达、抗炎抗氧化、调节肠道微环境等机制是该领域的研究热点。突发检测分析进一步表明，基于纳米颗粒的靶向药物递送系统（如叶酸缀合纳米载体）在结直肠癌治疗中的应用既是当前的热点，也是未来的趋势。本研究对该领域进行了全面概述，突出了研究热点和趋势，为研究者进一步把握研究方向提供了有价值的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Carcinogenesis 医学-肿瘤学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

1 months

期刊介绍： Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man. The journal publishes papers that warrant prompt publication in the areas of Biology, Genetics and Epigenetics (including the processes of promotion, progression, signal transduction, apoptosis, genomic instability, growth factors, cell and molecular biology, mutation, DNA repair, genetics, etc.), Cancer Biomarkers and Molecular Epidemiology (including genetic predisposition to cancer, and epidemiology), Inflammation, Microenvironment and Prevention (including molecular dosimetry, chemoprevention, nutrition and cancer, etc.), and Carcinogenesis (including oncogenes and tumor suppressor genes in carcinogenesis, therapy resistance of solid tumors, cancer mouse models, apoptosis and senescence, novel therapeutic targets and cancer drugs).