Development of Clindamycin-Loaded Microneedles for the Treatment of Nodular Acne: A Novel Therapeutic Approach.

IF 1.5 Q3 DERMATOLOGY
Dermatology Research and Practice Pub Date : 2025-04-08 eCollection Date: 2025-01-01 DOI:10.1155/drp/2138049
Tanikan Sangnim, Chonlada Panpipat, Supawut Chonsupawan, Siriyakorn Doungmarl, Metasit Nawayut, Kittipat Suwanpitak, Thannicha Huanbutta, Kampanart Huanbutta
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Abstract

Background: Acne is a common and often chronic skin condition that requires prolonged treatment. Conventional topical therapies are limited by their inability to effectively penetrate the deeper layers of the skin, reducing their effectiveness in treating comedones and inflammatory acne lesions. This study aimed to fabricate dissolvable microneedles (MNs) as a novel approach for delivering clindamycin directly to the obstructed sebaceous glands beneath the skin's surface. Methods: MNs were fabricated using 3D-printed molds of various shapes and lengths, employing materials such as chitosan, polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA). Pyramid-shaped MNs, 2500 μm in length, were created using PVA soaked in sodium sulfate. Their physical properties, insertion capabilities, and dissolution profiles were evaluated through texture analysis, in vitro penetration testing, and drug release studies. Results: Pyramid-shaped MNs made from PVA demonstrated the highest mechanical strength and structural integrity, confirmed through scanning electron microscopy and texture analysis. In vitro penetration testing showed that these MNs penetrated beyond four layers of Parafilm, simulating their ability to breach the stratum corneum. Dissolution studies indicated complete MN dissolution within 7-8 min, with rapid drug release occurring within 3 min. Conclusion: The study demonstrates the feasibility of creating dissolvable MNs for delivering clindamycin, offering a promising alternative to conventional therapies by improving drug penetration and providing rapid drug release for the treatment of acne.

用于治疗结节性痤疮的克林霉素微针的开发:一种新的治疗方法。
背景:痤疮是一种常见的慢性皮肤病,需要长期治疗。传统的局部疗法由于无法有效地穿透皮肤深层而受到限制,从而降低了治疗粉刺和炎症性痤疮病变的有效性。本研究旨在制造可溶解微针(MNs),作为一种将克林霉素直接输送到皮肤表面下阻塞皮脂腺的新方法。方法:采用壳聚糖、聚乙烯吡罗烷酮(PVP)和聚乙烯醇(PVA)等材料,利用3d打印模具制备不同形状和长度的纳米颗粒。聚乙烯醇在硫酸钠溶液中浸泡,得到了长度为2500 μm的金字塔形纳米颗粒。通过结构分析、体外渗透测试和药物释放研究来评估它们的物理性质、插入能力和溶出谱。结果:经扫描电镜和织构分析证实,PVA制成的金字塔形MNs具有最高的机械强度和结构完整性。体外渗透测试表明,这些纳米颗粒穿透了四层外膜,模拟了它们突破角质层的能力。溶出度研究表明,MN在7-8分钟内完全溶解,在3分钟内快速释放。结论:本研究证明了制备克林霉素可溶MNs的可行性,为治疗痤疮提供了一种有希望的替代传统疗法的方法,可以提高药物的穿透性,并提供药物的快速释放。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
16
审稿时长
11 weeks
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