Immune cell infiltration as a prognostic factor in endometrial cancer: a meta-analysis.

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2025-03-15 eCollection Date: 2025-01-01 DOI:10.62347/BXZM8857

Yibin Lin, Qiaoming Lin, Qi Guan, Danru Chen, Yan Zhou, Sang Li

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Abstract

The immune system's role in cancer development and progression is receiving increasing attention. Endometrial cancer, common gynecological malignancy, has exhibited promising responses to immunotherapies. This study aims to assess the prognostic significance of various immune cell subsets in endometrial cancer, focusing on potential novel biomarkers and therapeutic targets. A systematic literature review and meta-analysis were conducted. Eleven eligible studies, comprising 2,319 patients with endometrial cancer, were included. The primary outcome was the association between levels of immune cell types, particularly CD8+ T cells, and overall prognosis. The meta-analysis found that high levels of tumor-infiltrating lymphocytes (TILs), particularly CD8+ T cells, were significantly associated with better overall prognosis in endometrial cancer patients. These findings suggest that the tumor immune microenvironment plays a crucial role in endometrial cancer prognosis. This meta-analysis indicates that higher levels of CD8+ T cells in the tumor microenvironment are linked to improved prognosis in endometrial cancer, underscoring the immune system's potential in prognostication and therapy.

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免疫细胞浸润作为子宫内膜癌的预后因素：一项荟萃分析。

免疫系统在癌症发生和发展中的作用正受到越来越多的关注。子宫内膜癌是一种常见的妇科恶性肿瘤，免疫治疗已显示出良好的疗效。本研究旨在评估各种免疫细胞亚群在子宫内膜癌中的预后意义，重点关注潜在的新型生物标志物和治疗靶点。我们进行了系统的文献综述和荟萃分析。纳入了11项符合条件的研究，包括2319名子宫内膜癌患者。主要结果是免疫细胞类型（特别是CD8+ T细胞）水平与总体预后之间的关系。荟萃分析发现，高水平的肿瘤浸润淋巴细胞（til），特别是CD8+ T细胞，与子宫内膜癌患者更好的整体预后显著相关。提示肿瘤免疫微环境在子宫内膜癌预后中起着至关重要的作用。这项荟萃分析表明，肿瘤微环境中CD8+ T细胞水平的升高与子宫内膜癌预后的改善有关，强调了免疫系统在预后和治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.