Prevalence, incidence, and risk factors of diabetic retinopathy and macular edema in patients with early and late-onset type 2 diabetes mellitus

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-04-10 DOI:10.1111/jdi.70027

Ching-Kit Tsui, Andina Hu, Yuntong Li, Wenyong Huang, Wei Wang, Kaiqun Liu, Liqiong Xie, Yuting Li, Nathan Congdon, Xiaoling Liang, GDES Group

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引用次数: 0

Abstract

Aims

To compare the prevalence, incidence, and factors of diabetic retinopathy (DR) and macular edema (DME) in patients with early-onset (EOD) and late-onset diabetes (LOD).

Methods

Participants with type 2 diabetes mellitus (T2DM) were recruited from a community-based study conducted in southern urban China. Participants were followed up for 2 years. The prevalence and incidence of DR and DME were compared between EOD (≤40 years) and LOD (>40 years) groups, and potential factors were evaluated using multivariate logistic regression.

Results

Among 2,703 participants, 173 (6.4%) with EOD had a higher prevalence of DR than 2,530 (93.6%) with LOD (27.8% vs 15.5%, P < 0.001). Participants with EOD had a higher incidence of DR, although this difference was not statistically significant (EOD: 8.1% vs LOD: 3.6%, P = 0.12). Insulin use and higher HbA1c levels were significantly associated with DR in both EOD and LOD groups (both P < 0.05). Additionally, longer diabetes duration, higher systolic blood pressure, and the presence of albuminuria independently associated with the presence of any DR in LOD patients (all P < 0.05). For DME, HbA1c level was a significant association in EOD, while in LOD, age, BMI, insulin use, and albuminuria were significant factors (all P < 0.05).

Conclusions

A higher prevalence of DR was observed among patients with early-onset T2DM in urban southern China. Timely diagnosis of DR and regular eye care services are needed for early-onset T2DM.

Abstract Image

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早发和晚发2型糖尿病患者糖尿病视网膜病变和黄斑水肿的患病率、发病率及危险因素

目的：比较早发性（EOD）和晚发性糖尿病（LOD）患者糖尿病视网膜病变（DR）和黄斑水肿（DME）的患病率、发病率及其影响因素。方法：在中国南方城市进行的一项社区研究中招募了2型糖尿病（T2DM）患者。参与者被随访了2年。比较EOD组（≤40岁）和LOD组（≤40岁）之间DR和DME的患病率和发病率，并采用多因素logistic回归分析潜在影响因素。结果：在2703名参与者中，173名EOD患者（6.4%）的DR患病率高于2530名LOD患者（93.6%）（27.8% vs 15.5%）。结论：中国南方城市早发型T2DM患者中DR患病率更高。对于早发性T2DM，需要及时诊断DR并定期进行眼保健服务。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).