Histopathological and IHC evaluation of malignant non-pigmented chromatophoroma in a savannah monitor (Varanus exanthematicus).

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Acta veterinaria Hungarica Pub Date : 2025-05-05 Print Date: 2025-06-13 DOI:10.1556/004.2025.01118

Marta Durska, Mateusz Mikiewicz, Katarzyna Paździor-Czapula, Michał Gesek, Iwona Otrocka-Domagała

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引用次数: 0

Abstract

Chromatophoromas are neoplasms arising from pigment cells (chromatophores) and commonly manifest as cutaneous lesions. While brown to black melanophoromas are most prevalent in reptiles, sporadic cases of non-pigmented chromatophoromas have been reported. This case study documents the clinical presentation, histopathological features and IHC (IHC) profile of an oral non-pigmented chromatophoroma in a 13-year-old male savannah monitor (Varanus exanthematicus). Histopathological examination revealed a poorly demarcated tumour located in the mucosa. Non-pigmented neoplastic cells with marked anisocytosis, anisokaryosis, increased nuclear-cytoplasmic ratio and numerous mitotic figures formed solid packets separated by collagenous septa. IHC analysis revealed that tumour cells were positive to melan-A, S100 protein, neuron-specific enolase and cytokeratins AE1/AE3. Based on the histopathological and IHC findings, the tumour was diagnosed as a non-pigmented chromatophoroma. Detailed histopathological and IHC profiling enhances our comprehension of the diversity within chromatophoromas and underscores the diagnostic complexities involved. Immunohistochemistry is a crucial tool for identifying non-pigmented chromatophoromas.

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大草原斑蝶恶性非色素色素瘤的组织病理学和免疫组化评价。

色素瘤是由色素细胞（色素细胞）引起的肿瘤，通常表现为皮肤病变。虽然褐色至黑色黑色素瘤在爬行动物中最为普遍，但也有零星的非色素色素瘤病例报道。本病例研究记录了一例13岁雄性草原斑蝶（Varanus exanthematicus）口腔非色素色斑瘤的临床表现、组织病理学特征和免疫组化（IHC）特征。组织病理学检查显示粘膜内有一个界限不清的肿瘤。无色素的肿瘤细胞呈明显的细胞增生、异核症、核质比增加和大量有丝分裂象，形成由胶原间隔隔开的实包。免疫组化分析显示，肿瘤细胞对黑色素a、S100蛋白、神经元特异性烯醇化酶和细胞角蛋白AE1/AE3呈阳性。根据组织病理学和免疫组化检查结果，诊断为非色素色素瘤。详细的组织病理学和免疫组化分析增强了我们对染色质瘤多样性的理解，并强调了所涉及的诊断复杂性。免疫组织化学是鉴别非色素染色质瘤的重要工具。

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来源期刊

Acta veterinaria Hungarica 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Acta Veterinaria Hungarica publishes original research papers presenting new scientific results of international interest, and to a limited extent also review articles and clinical case reports, on veterinary physiology (physiological chemistry and metabolism), veterinary microbiology (bacteriology, virology, immunology, molecular biology), on the infectious diseases of domestic animals, on veterinary parasitology, pathology, clinical veterinary science and reproduction.