Seroprevalence, seroconversion, and mother-to-child transmission of dual and triplex infections of HIV, HBV, and HCV among Nigerian obstetric population: A national multicentre prospective cohort study.

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2025-04-01 Epub Date: 2025-04-17 DOI:10.1177/13596535251333259

George Uchenna Eleje, Hadiza Abdullahi Usman, Chinyere Ukamaka Onubogu, Preye Owen Fiebai, Godwin Otuodichinma Akaba, Ayyuba Rabiu, Ikechukwu Innocent Mbachu, Osita Samuel Umeononihu, Rebecca Chinyelu Chukwuanukwu, Chukwuanugo Nkemakonam Ogbuagu, Ngozi Nneka Joe-Ikechebelu, Emeka Philip Igbodike, Richard Obinwanne Egeonu, Ijeoma Chioma Oppah, Uchenna Chukwunonso Ogwaluonye, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chisom God'swill Chigbo, Moriam Taiwo Chibuzor, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Aishat Ahmed, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Ubong Inyang Anyang, Ekene Agatha Emeka, Odion Emmanuel Igue, Ogbonna Dennis Okoro, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Harrison Chiro Ugwuoroko, Aisha Ismaila Numan, Solace Amechi Omoruyi, Chukwuemeka Chukwubuikem Okoro, Ifeanyi Kingsley Nwaeju, Arinze Anthony Onwuegbuna, Lydia Ijeoma Eleje, David Chibuike Ikwuka, Eric Okechukwu Umeh, Sussan Ifeyinwa Nweje, Ifeoma Clara Ajuba, Angela Ogechukwu Ugwu, Uzoamaka Rufina Ebubedike, Divinefavour Echezona Malachy, Chiamaka Henrietta Jibuaku, Chigozie Geoffrey Okafor, Nnaedozie Paul Obiegbu, Obinna Kenneth Nnabuchi, Chukwuemeka Okwudili Ezeama, Kingsley Chidiebere Nwaogu, Rashida Khalid Yakubu, Ifunanya Anita Ezeamama, Amaka Elizabeth Agbata, Maryrose Onyinyechukwu Ikem, Kingsley Chukwuebuka Agu, Ekenedilichukwu Anselem Odiegwu, Chinedu Charles Nwankwo, Emmanuel Onyebuchi Ugwu, Ibrahim Adamu Yakasai, Olabisi Morebise Loto, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu

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引用次数: 0

Abstract

ObjectivesTo determine seroprevalence, seroconversion, and mother-to-child transmission (MTCT) rates for dual and triplex infections of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) among pregnant women.MethodsA multicentre prospective cohort study was conducted in six randomly selected tertiary hospitals from six geopolitical zones of Nigeria. Consenting participants were tested at recruitment for triplex infections and followed-up till delivery. Retests were performed at delivery for those who tested negative for all three infections/positive for only one. Polymerase chain reaction was used for validation while rapid test kits were employed for initial screening.ResultsOf the 2775 participants recruited, 13 (0.47%; 95% CI: 0.25%-0.80%) and 4 (0.14%; 95% CI: 0.04%-0.37%) were seropositive for dual and triplex infections, respectively. Dual infections revealed seroprevalences of 0.22% for HIV-HBV (6/2775; 95% CI: 0.08%-0.47%), 0.14% for HIV-HCV (4/2775; 95% CI: 0.04%-0.37%), and 0.11% for HBV-HCV (3/2775; 95% CI: 0.02%-0.32%). Multivariable analysis highlighted significant associations between HIV/HBV co-infection and religion (adjusted odds ratio (aOR): 0.068, 95% CI: 0.006-0.757) and house ownership (aOR): 1.65 × 10^-9, 95% CI: 1.60 × 10^-9-1.70 × 10^-9). Continuing our follow-up until delivery for 2403 initial participants, 2386 did not have dual or triplex infections at the start. Upon retesting at delivery, three of these women were seropositive for a dual infection of HIV and HBV, giving a seroconversion rate of 0.12% (95% CI: 0.03% to 0.37%). MTCT rate stood at 0% at 6-week post-delivery.ConclusionWe observed a relatively low seroprevalence and seroconversion rates for dual and triplex infections of HIV, HBV, and HCV among pregnant women in Nigeria and no MTCT.

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尼日利亚产科人群中HIV、HBV和HCV双重和三重感染的血清阳性率、血清转化和母婴传播：一项国家多中心前瞻性队列研究

目的测定孕妇人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）双重和三重感染的血清阳性率、血清转化和母婴传播（MTCT）率。方法在尼日利亚6个地缘政治地区随机选择6家三级医院进行多中心前瞻性队列研究。同意的参与者在招募时接受三重感染测试，并随访至分娩。在分娩时对所有三种感染检测均为阴性/只有一种感染检测呈阳性的人进行重新检测。采用聚合酶链反应进行验证，采用快速检测试剂盒进行初步筛选。结果在招募的2775名受试者中，13名(0.47%；95% CI: 0.25%-0.80%)和4 (0.14%；95% CI: 0.04%-0.37%)分别为双重感染和三重感染血清阳性。双重感染显示HIV-HBV的血清患病率为0.22% (6/2775；95% CI: 0.08%-0.47%)， HIV-HCV为0.14% (4/2775；95% CI: 0.04%-0.37%)， HBV-HCV为0.11% (3/2775；95% ci: 0.02%-0.32%)。多变量分析强调了HIV/HBV合并感染与宗教（调整优势比（aOR）： 0.068, 95% CI: 0.006-0.757）和房屋所有权（aOR）： 1.65 × 10-9, 95% CI: 1.60 × 10-9-1.70 × 10-9)之间的显著相关性。继续我们的随访，直到2403名最初的参与者分娩，2386名开始时没有双重或三重感染。在分娩时重新检测时，其中3名妇女的HIV和HBV双重感染血清呈阳性，血清转化率为0.12% （95% CI: 0.03%至0.37%）。分娩后6周，母婴传播率为0%。结论：我们观察到尼日利亚孕妇中HIV、HBV和HCV双重和三重感染的血清阳性率和血清转化率相对较低，且没有MTCT。

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.