Crystal structure and Hirshfeld surface analysis of ketorolac tromethamine

Abstract

The mol­ecular and crystal structures of ketorolac tromethamine are reported. In the crystal, mol­ecules are connected by N—H⋯O and O—H⋯O hy­dro­gen bonds, forming a two-dimensional layer in the (100) plane.

Ketorolac tromethamine or 1,3-dihy­droxy-2-(hy­droxy­meth­yl)propan-2-am­inium 5-benzoyl-2,3-di­hydro-1H-pyrrolizine-1-carboxyl­ate, C₁₅H₁₂NO₃⁺·C₄H₁₂NO₃⁻, was studied by single-crystal and powder X-ray diffraction methods. One cation and one anion are present in the asymmetric unit. In the crystal, N—H⋯O and O—H⋯O hy­dro­gen bonds link the cation and anion. All the hy­dro­gen-bond inter­actions result in the formation of a di-periodic layer in the (100) crystallographic plane.