Longitudinal trends in dementia prevalence among individuals with type 2 diabetes in Taiwan (2009–2022)

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-05-03 DOI:10.1111/jdi.70060

Chen-Yang Hsiao, Sun-Wung Hsieh, Yuan-Han Yang, Hui-Min Hsieh

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Abstract

Objective

This study examined the population-based epidemiological prevalence of early- and late-onset dementia in individuals with type 2 diabetes mellitus (T2DM) compared with the general population in Taiwan from 2009 to 2022.

Methods

A 14-year nationwide population-based epidemiology study from 2009 to 2022 in Taiwan using the Taiwan National Health Insurance Research Database was conducted to examine the crude and age-standardized dementia prevalence in individuals aged <65 and ≥65. Multivariable logistic regression was used to assess factors associated with dementia prevalence in the T2DM population.

Results

Among individuals aged ≥65 with T2DM, age-standardized dementia prevalence increased from 5.83 per 100 in 2009 to 7.11 per 100 in 2022, while the crude prevalence ratio compared to the general population ranged from 1.19 to 1.08. In the 40–64 age group, standardized dementia prevalence ranged from 0.58 to 0.43 per 100, with crude ratios ranging from 1.76 to 1.41.

Our study found a higher risk of dementia prevalence among individuals aged 65 years and older, particularly among those with T2DM. Although the overall prevalence of dementia in the 40–64 age group was lower compared to older adults, individuals in this younger group with T2DM exhibited a significantly higher risk of developing dementia. Given these findings, public policy should prioritize early preventive strategies for individuals with T2DM to monitor and mitigate dementia progression in patients with T2DM.

Abstract Image

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台湾2型糖尿病患者痴呆患病率的纵向趋势（2009-2022）。

目的：研究2009 - 2022年台湾地区2型糖尿病（T2DM）患者早、晚发性痴呆的人群流行病学患病率。在40-64岁年龄组中，标准化痴呆患病率为0.58 - 0.43 / 100，粗比值为1.76 - 1.41。我们的研究发现，65岁及以上的人患痴呆症的风险更高，尤其是那些患有2型糖尿病的人。尽管与老年人相比，40-64岁年龄组的痴呆症总体患病率较低，但这一年轻组的2型糖尿病患者患痴呆症的风险明显较高。鉴于这些发现，公共政策应优先考虑T2DM患者的早期预防策略，以监测和减轻T2DM患者的痴呆进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).