Effect of renal function on serum pro-gastrin-releasing peptide expression and its clinical relevance.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2025-04-30 DOI:10.5414/CN111593

Jie Liu, Tengda Xu, Songbai Lin

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引用次数: 0

Abstract

Objective: This study aims to evaluate the effect of renal function on serum pro-gastrin-releasing peptide (ProGRP) expression and to assess its clinical significance.

Materials and methods: A total of 3,906 individuals who underwent physical examinations at Peking Union Medical College Hospital between May 2017 and May 2020 were enrolled in this study. Participants were categorized into four groups based on their creatinine clearance rate (Ccr): the Ccr1 group (34 cases, < 30 mL/min), the Ccr2 group (715 cases, 30 - 60 mL/min), the Ccr3 group (2,289 cases, 60 - 90 mL/min), and the Ccr4 group (868 cases, > 90 mL/min). Levels of blood urea nitrogen (BUN), serum creatinine (Scr), cystatin C (Cys-C), and ProGRP were measured and compared across the groups. Additionally, endogenous Ccr values were calculated for all participants.

Results: Serum levels of BUN, Scr, Cys-C, and ProGRP, as well as Ccr values, exhibited significant differences among the groups (p < 0.05). A negative correlation was found between Ccr and serum ProGRP (p = 0.001).

Conclusion: Higher serum ProGRP levels were associated with more severe renal dysfunction. These findings underscore the importance of considering renal function when interpreting serum ProGRP levels for clinical diagnosis and prognosis.

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肾功能对血清胃泌素释放肽表达的影响及其临床意义。

目的：探讨肾功能对血清促胃泌素释放肽（ProGRP）表达的影响，探讨其临床意义。材料与方法：2017年5月至2020年5月在北京协和医院接受体检的3906名患者被纳入本研究。参与者根据其肌酐清除率（Ccr）分为四组：Ccr1组（34例，< 30 mL/min）， Ccr2组（715例，30 - 60 mL/min）， Ccr3组（2,289例，60 - 90 mL/min）和Ccr4组（868例，bb0 90 mL/min）。测定各组血尿素氮（BUN）、血清肌酐（Scr）、胱抑素C （Cys-C）和ProGRP水平并进行比较。此外，计算所有参与者的内生Ccr值。结果：各组间血清BUN、Scr、Cys-C、ProGRP水平及Ccr值差异均有统计学意义（p < 0.05）。Ccr与血清ProGRP呈负相关（p = 0.001）。结论：血清ProGRP水平越高，肾功能不全越严重。这些发现强调了在解释血清ProGRP水平时考虑肾功能对临床诊断和预后的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.