Correlation Between Free Thyroxine Levels and Mortality in Hypertensive Patients.

IF 2.3 4区 医学 Q2 HEMATOLOGY
Zhuang Chen, Jing Feng, Quanxin Wang, Ling Zhu, Anzhong Yu, Shimin Liang, Jian Li, Shiliang Zhang, Feng Wu
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Abstract

Objective: To study the link between free thyroxine (FT4) levels and mortality in hypertensive patients. Methods: Utilizing data from the National Health and Nutrition Examination Survey performed in the United States from 2007 to 2012. Results: This study included 3365 adults from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Weighted Cox regression model, Kaplan-Meier (KM) survival analysis, and restricted cubic spline (RCS) were used to analyze the link between FT4 levels and mortality in hypertensive patients. Furthermore, subgroup analyses and interaction analyses were carried out to evaluate the stability of links between FT4 levels and all-cause mortality across different subgroups of hypertensive patients. In the weighted Cox regression model, after adjusting for all covariates, FT4 levels treated as a continuous variable were positively linked to all-cause mortality in hypertensive patients (HR = 1.08,95% CI: 1.04-1.12, P < .001). When FT4 levels were treated as a categorical variable according to quartiles, the fully adjusted model found that the highest quartile of FT4 posed a greater all-cause mortality risk in hypertensive patients relative to the lowest quartile (HR = 1.47, 95% CI:1.01-2.15, P = .045). Based on the Kaplan-Meier survival curve, all-cause mortality was notably higher in groups Q3 and Q4 relative to FT4 levels in groups Q1 and Q2 (P < .001). The RCS curve revealed that the all-cause mortality in hypertensive patients exhibited a nonlinear increasing trend with rising FT4 levels (P for nonlinear = .033). The results were further validated by subgroup and sensitivity analyses, which confirmed their robustness and reliability. Conclusion: The level of FT4 is strongly linked to the all-cause mortality risk in hypertensive patients.

高血压患者游离甲状腺素水平与死亡率的相关性
目的:探讨高血压患者游离甲状腺素(FT4)水平与死亡率的关系。方法:利用2007年至2012年在美国进行的国家健康和营养检查调查的数据。结果:本研究纳入了2007-2012年国家健康与营养检查调查(NHANES)的3365名成年人。采用加权Cox回归模型、Kaplan-Meier (KM)生存分析和限制性三次样条(RCS)分析FT4水平与高血压患者死亡率之间的关系。此外,还进行了亚组分析和相互作用分析,以评估不同亚组高血压患者中FT4水平与全因死亡率之间联系的稳定性。在加权Cox回归模型中,校正所有协变量后,FT4水平作为连续变量与高血压患者的全因死亡率呈正相关(HR = 1.08,95% CI: 1.04-1.12, P = 0.045)。根据Kaplan-Meier生存曲线,Q3和Q4组的全因死亡率明显高于Q1和Q2组的FT4水平(非线性P = 0.033)。亚组分析和敏感性分析进一步验证了结果的稳健性和可靠性。结论:FT4水平与高血压患者全因死亡风险密切相关。
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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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