Morphological and functional assessment of the vagus nerve in multiple sclerosis.

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Autonomic Research Pub Date : 2025-05-01 DOI:10.1007/s10286-025-01130-y

Ana Abičić, Magdalena Krbot Skorić, Tereza Gabelić, Barbara Barun, Mario Habek, Ivan Adamec

{"title":"Morphological and functional assessment of the vagus nerve in multiple sclerosis.","authors":"Ana Abičić, Magdalena Krbot Skorić, Tereza Gabelić, Barbara Barun, Mario Habek, Ivan Adamec","doi":"10.1007/s10286-025-01130-y","DOIUrl":null,"url":null,"abstract":"Purpose: The aim of this work is to determine the relationship between the cross-sectional area (CSA) of the vagus nerve and cardiovagal function in people with multiple sclerosis (pwMS) and healthy controls (HC).Methods: We enrolled 50 pwMS and 50 HC. All participants underwent an ultrasound of the vagus nerve and autonomic nervous system testing. The Croatian version of the COMPASS-31 questionnaire was used as a measure of autonomic symptom burden. Cardiovagal function was evaluated with the respiratory sinus arrhythmia (RSA), Valsalva ratio (VR), and heart rate variability.Results: The mean vagus CSA in pwMS was 2.03 ± 0.49 mm2 on the right side and 1.72 ± 0.38 mm2 on the left side. The mean vagus CSA in HC was 2.08 ± 0.50 mm2 on the right side and 1.74 ± 0.37 mm2 on the left side. There was no statistically significant difference between the two groups in right (p = 0.615) or left (p = 0.866) vagus CSA. In the HC, there was a statistically significant positive correlation between the mean right CSA and both RSA (rp = 0.331, p = 0.019) and VR (rp = 0.327, p = 0.020). On univariable linear regression analysis in the HC group, the mean right CSA was a predictor of both RSA (B = 5.599, 95% CI 0.974-10.224, p = 0.019) and VR (B = 0.253, 95% CI 0.041-0.466, p = 0.020). These findings were not present in pwMS.Conclusions: The loss of correlation between vagus nerve CSA and parameters of parasympathetic nervous system function in pwMS corroborates the presence of cardiovagal dysfunction in multiple sclerosis.","PeriodicalId":10168,"journal":{"name":"Clinical Autonomic Research","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Autonomic Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10286-025-01130-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The aim of this work is to determine the relationship between the cross-sectional area (CSA) of the vagus nerve and cardiovagal function in people with multiple sclerosis (pwMS) and healthy controls (HC).

Methods: We enrolled 50 pwMS and 50 HC. All participants underwent an ultrasound of the vagus nerve and autonomic nervous system testing. The Croatian version of the COMPASS-31 questionnaire was used as a measure of autonomic symptom burden. Cardiovagal function was evaluated with the respiratory sinus arrhythmia (RSA), Valsalva ratio (VR), and heart rate variability.

Results: The mean vagus CSA in pwMS was 2.03 ± 0.49 mm² on the right side and 1.72 ± 0.38 mm² on the left side. The mean vagus CSA in HC was 2.08 ± 0.50 mm² on the right side and 1.74 ± 0.37 mm² on the left side. There was no statistically significant difference between the two groups in right (p = 0.615) or left (p = 0.866) vagus CSA. In the HC, there was a statistically significant positive correlation between the mean right CSA and both RSA (r_p = 0.331, p = 0.019) and VR (r_p = 0.327, p = 0.020). On univariable linear regression analysis in the HC group, the mean right CSA was a predictor of both RSA (B = 5.599, 95% CI 0.974-10.224, p = 0.019) and VR (B = 0.253, 95% CI 0.041-0.466, p = 0.020). These findings were not present in pwMS.

Conclusions: The loss of correlation between vagus nerve CSA and parameters of parasympathetic nervous system function in pwMS corroborates the presence of cardiovagal dysfunction in multiple sclerosis.

查看原文本刊更多论文

多发性硬化症迷走神经形态学和功能评价。

目的：研究多发性硬化症（pwMS）患者和健康对照（HC）迷走神经横截面积（CSA）与心血管功能的关系。方法：50例pwMS和50例HC。所有参与者都接受了迷走神经和自主神经系统的超声检查。使用克罗地亚版COMPASS-31问卷作为自主症状负担的测量方法。通过呼吸窦性心律失常（RSA）、Valsalva比率（VR）和心率变异性评估心血管功能。结果：pwMS患者迷走神经CSA平均右侧为2.03±0.49 mm2，左侧为1.72±0.38 mm2。HC患者迷走神经CSA平均右侧为2.08±0.50 mm2，左侧为1.74±0.37 mm2。两组右侧迷走神经CSA （p = 0.615）和左侧迷走神经CSA （p = 0.866）比较，差异均无统计学意义。在HC中，右侧平均CSA与RSA （rp = 0.331, p = 0.019）和VR （rp = 0.327, p = 0.020）均有统计学意义的正相关。在HC组的单变量线性回归分析中，平均右侧CSA是RSA （B = 5.599, 95% CI 0.974-10.224, p = 0.019）和VR （B = 0.253, 95% CI 0.041-0.466, p = 0.020）的预测因子。这些发现在pwMS中不存在。结论：迷走神经CSA与副交感神经系统功能参数相关性的丧失证实了多发性硬化症存在心血管功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Autonomic Research 医学-临床神经学

CiteScore

7.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： Clinical Autonomic Research aims to draw together and disseminate research work from various disciplines and specialties dealing with clinical problems resulting from autonomic dysfunction. Areas to be covered include: cardiovascular system, neurology, diabetes, endocrinology, urology, pain disorders, ophthalmology, gastroenterology, toxicology and clinical pharmacology, skin infectious diseases, renal disease. This journal is an essential source of new information for everyone working in areas involving the autonomic nervous system. A major feature of Clinical Autonomic Research is its speed of publication coupled with the highest refereeing standards.