Cascade cyclization/fluoromethylthiolation of alkynes, unsaturated α‑bromocarbonyls and PhSO2SRF

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-05-14 DOI:10.1039/d5qo00585j

Cui Zhang, Yun-Tao Shen, Ning-Xin Xia, Xin-Song Zhou, Li-Bo Yang, Jia Hu, Ya-Min Li

引用次数: 0

Abstract

A copper-catalyzed cyclization/fluoromethylthiolation cascade of alkynes, unsaturated α‑bromocarbonyls and PhSO2SCF2H/PhSO2SCF3 has been developed for access to fluoromethylthiolated cyclopentenes and cyclohexenes. The present reaction enables the construction of three new chemical bonds in a single step through the addition of alkyl radicals across alkynes, followed by cyclization and fluoromethylthiolation. It is characterized by high chemoselectivity and a broad substrate scope.

查看原文本刊更多论文

烷基、不饱和α -溴羰基和PhSO2SRF的级联环化/氟甲基硫基化

铜催化烷基、不饱和α -溴羰基和PhSO2SCF2H/PhSO2SCF3的环化/氟甲基硫代级联反应制备了氟甲基硫代环戊烯和环己烯。目前的反应可以通过在炔烃上添加烷基自由基，然后进行环化和氟甲基硫代化，在一步中构建三个新的化学键。它具有高化学选择性和广泛的底物范围的特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.