Multifaceted roles of Epac signaling in renal functions.

IF 4.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Journal Pub Date : 2025-05-14 DOI:10.1042/bcj20253103

Oleh Pochynyuk,Kyrylo Pyrshev,Xiaodong Cheng

引用次数: 0

Abstract

3',5'-cyclic adenosine monophosphate (cAMP) is a fundamental secondary messenger capable of rapidly amplifying and propagating cellular signals in response to various extracellular stimuli. cAMP plays a significant role in hormone-mediated regulation of renal fluid and electrolyte balance. Impaired signaling of cAMP has been linked to a variety of pathological ramifications in the kidneys. This review explores the physiological functions of exchange proteins directly activated by cAMP (Epac) in renal water balance and the regulation of solute transport in the renal tubule. Additionally, the involvement of Epac signaling in renal pathologies such as acute kidney injury, chronic kidney disease, and polycystic kidney disease is discussed.

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Epac信号在肾功能中的多重作用。

3',5'-环腺苷单磷酸（cAMP）是一种基本的次生信使，能够快速放大和传播细胞信号，以响应各种细胞外刺激。cAMP在激素介导的肾液和电解质平衡调节中起重要作用。cAMP信号传导受损与肾脏的多种病理后果有关。本文综述了cAMP直接激活的交换蛋白（Epac）在肾脏水平衡和调节肾小管溶质转运中的生理功能。此外，Epac信号在肾脏病理如急性肾损伤、慢性肾病和多囊肾病中的参与也被讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemical Journal 生物-生化与分子生物学

CiteScore

8.00

自引率

0.00%

发文量

255

审稿时长

1 months

期刊介绍： Exploring the molecular mechanisms that underpin key biological processes, the Biochemical Journal is a leading bioscience journal publishing high-impact scientific research papers and reviews on the latest advances and new mechanistic concepts in the fields of biochemistry, cellular biosciences and molecular biology. The Journal and its Editorial Board are committed to publishing work that provides a significant advance to current understanding or mechanistic insights; studies that go beyond observational work using in vitro and/or in vivo approaches are welcomed. Painless publishing: All papers undergo a rigorous peer review process; however, the Editorial Board is committed to ensuring that, if revisions are recommended, extra experiments not necessary to the paper will not be asked for. Areas covered in the journal include: Cell biology Chemical biology Energy processes Gene expression and regulation Mechanisms of disease Metabolism Molecular structure and function Plant biology Signalling