Gold(I)-Catalyzed Asymmetric Heterocyclization/(5 + 3) Cycloaddition of Yne-enones with Imidazolidines: Access to Cycloocta[c]furan Frameworks.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-12 DOI:10.1021/acs.orglett.5c01267

Yuncheng Liu,Xiaoai Liu,Songyi Gao,Junyang Liu,Ming Lang,Shiyong Peng

引用次数: 0

Abstract

Herein, we report a gold(I)-catalyzed heterocyclization/(5 + 3) cycloaddition cascade of yne-enones with imidazolidines, providing a modular, atom-economical and efficient strategy for the synthesis of cycloocta[c]furans in moderate to excellent yields. This method features readily available substrates, simple operation, mild reaction conditions, and broad substrate scope. More importantly, the asymmetric version is also achieved by employing (R)-C2-TunePhos ligand (L7), leading to optically active cycloocta[c]furans with up to 98:2 er.

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金(I)-催化炔烯酮与咪唑烷的不对称杂环化/(5 + 3)环加成反应：环状物的制备[c]呋喃骨架。

本文报道了一种金(I)催化的炔烯酮与咪唑烷的杂环化/(5 + 3)环加成级联反应，为合成环[c]呋喃提供了一种模块化、原子经济和高效的策略，收率中等至优异。该方法具有底物易得、操作简单、反应条件温和、底物适用范围广等特点。更重要的是，采用(R)-C2-TunePhos配体（L7）也可以实现不对称版本，从而获得光学活性高达98:2 er的环[c]呋喃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.