Influence of the neurotensin signaling system on feeding and satiety

IF 4.6 2区医学 Q1 NEUROSCIENCES

Neuropharmacology Pub Date : 2025-05-03 DOI:10.1016/j.neuropharm.2025.110496

Katie D. Thompson , Gina M. Leinninger

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Abstract

Neurotensin (Nts) is a peptide that acts via neurotensin receptors and is implicated in multiple aspects of physiology and behavior, including modulating feeding and body weight. How and where the Nts signaling system mediates these effects, and via which of its receptor isoforms is incompletely understood. This review examines the role of Nts signaling via the periphery and central nervous system on feeding and body weight. These data highlight various ways in which the Nts system contributes to feeding and body weight that differ depending on the site, tissue, and the Nts or Nts receptor-expressing cell type in question. Given that the Nts system does not convey the same signaling throughout the body, constitutive approaches modulating the expression or signaling of the Nts signaling system may not provide sufficient resolution to reveal how it impacts feeding. Combining neuropharmacology and site-specific approaches holds promise define the broad range of mechanisms by the Nts system modulates feeding and satiety and its contributions to normal and disrupted feeding states.

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神经紧张素信号系统对摄食和饱腹感的影响

神经紧张素（Nts）是一种通过神经紧张素受体起作用的肽，涉及生理和行为的多个方面，包括调节摄食和体重。Nts信号系统如何以及在何处介导这些作用，以及通过哪一种受体同种异构体介导这些作用尚不完全清楚。本文综述了通过外周和中枢神经系统的Nts信号在摄食和体重中的作用。这些数据突出了Nts系统促进摄食和体重的各种方式，这些方式取决于部位、组织和Nts或Nts受体表达的细胞类型。鉴于Nts系统不会在全身传递相同的信号，调节Nts信号系统的表达或信号传导的组成方法可能无法提供足够的分辨率来揭示它如何影响摄食。结合神经药理学和特定部位的方法有希望定义Nts系统调节进食和饱腹感及其对正常和中断进食状态的贡献的广泛机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropharmacology 医学-神经科学

CiteScore

10.00

自引率

4.30%

发文量

288

审稿时长

45 days

期刊介绍： Neuropharmacology publishes high quality, original research and review articles within the discipline of neuroscience, especially articles with a neuropharmacological component. However, papers within any area of neuroscience will be considered. The journal does not usually accept clinical research, although preclinical neuropharmacological studies in humans may be considered. The journal only considers submissions in which the chemical structures and compositions of experimental agents are readily available in the literature or disclosed by the authors in the submitted manuscript. Only in exceptional circumstances will natural products be considered, and then only if the preparation is well defined by scientific means. Neuropharmacology publishes articles of any length (original research and reviews).