Composite lifestyle, genetic risk, blood biomarkers, and risk of suicide attempts: a prospective cohort study

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-05-09 DOI:10.1016/j.bbi.2025.05.005

Wei Hu , Tian-Shu Liu , Zhen-Zhen Shen, Ge Tian, Jia-Ning Wang, Zhen-Yu Zhao, Bao-Peng Liu, Cun-Xian Jia

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引用次数: 0

Abstract

Background

Although individual lifestyle factors may be associated with suicide attempts (SA), the prospective association of composite lifestyles with SA remains unknown. Furthermore, whether this association is modulated by genetic risk remains to be elucidated. The study aimed to investigate the association of composite lifestyles and genetic risk with SA risk and to explore the underlying biological mechanisms.

Methods

435,154 individuals from the UK Biobank without a history of SA at baseline were enrolled. The SA diagnosis was based on the International Classification of Diseases coding system. Composite lifestyles were developed based on seven modifiable lifestyle factors and categorized into favorable, intermediate, and unfavorable groups. According to the polygenic risk score for SA, genetic risk was classified as low, intermediate, or high. Cox proportional hazard models and mediation analyses were conducted to examine the associations and mechanisms, respectively.

Findings

During a mean follow-up of 13.6 years, 1,515 (0.35 %) individuals experienced SA. Compared to individuals with favorable lifestyles, the HR (95 % CI) for SA among those with unfavorable lifestyles was 2.19 (1.93–2.48). The risk of SA was 68 % higher among those with high genetic risk compared with low-risk individuals (HR = 1.68, 95 % CI: 1.48–1.92). The joint test revealed that individuals with unfavorable lifestyles and high genetic risk faced the highest risk of SA (HR = 3.58, 95 % CI: 2.91–4.40), which could be explained by an additive interaction. Several biomarkers in liver function, endocrine, inflammation, and blood cell pathways collectively explained 15.84 % (95 % CI: 7.68 %-27.68 %) of the association.

Interpretation

Adherence to favorable lifestyles was associated with a lower risk of SA, especially among those at high genetic risk. The beneficial association might be partially explained by improvement in key mediating biomarkers.

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复合生活方式、遗传风险、血液生物标志物和自杀企图风险：一项前瞻性队列研究

背景：虽然个人生活方式因素可能与自杀企图（SA）有关，但复合生活方式与SA的潜在关联尚不清楚。此外，这种关联是否受到遗传风险的调节仍有待阐明。本研究旨在探讨复合生活方式和遗传风险与SA风险的关系，并探讨其潜在的生物学机制。方法从英国生物银行中招募了435,154名基线时无SA病史的个体。SA诊断基于国际疾病分类编码系统。复合生活方式是基于7个可改变的生活方式因素，并分为有利、中等和不利三类。根据SA的多基因风险评分，遗传风险分为低、中、高三个级别。分别采用Cox比例风险模型和中介分析来检验相关性和机制。在平均13.6年的随访期间，1515人（0.35%）经历了SA。与生活方式良好者相比，生活方式不良者SA的HR （95% CI）为2.19（1.93 ~ 2.48）。高遗传风险人群发生SA的风险比低遗传风险人群高68% （HR = 1.68, 95% CI: 1.48-1.92）。联合检验结果显示，生活方式不良、遗传风险高的个体发生SA的风险最高（HR = 3.58, 95% CI: 2.91 ~ 4.40），二者存在加性相互作用。肝功能、内分泌、炎症和血细胞途径的几种生物标志物共同解释了15.84% （95% CI: 7.68% - 27.68%）的相关性。坚持良好的生活方式与低SA风险相关，特别是在那些高遗传风险的人群中。这种有益的关联可能部分地解释为关键中介生物标志物的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.