A review on synthesis, functionalization, and theranostic prospects of holmium nanoparticles

Results in Surfaces and Interfaces Pub Date : 2025-05-01 DOI:10.1016/j.rsurfi.2025.100545

Retna Putri Fauzia , Ayu Jelita Sinambela , Zahra Afriani , Ratna Dini Haryuni , Sumandi Juliyanto , Santhy Wyantuti , Husein H. Bahti

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Abstract

Nanoparticle-based theranostics agents have emerged as a promising approach in modern hospitals, offering integrated solutions for disease diagnosis and therapy. Among the various types of materials investigated for theranostics applications, holmium nanoparticles (HoNPs) have gained significant attention due to their advantageous magnetic, optical, and chemical properties. Therefore, this review aims to explore synthesis, functionalization, and theranostic prospects of HoNPs. Synthesis approach, including polyol, precipitation, thermal decomposition, and solvothermal, was extensively discussed. Nanoparticles properties (such as size, shape, and morphology), relativity value, biodistribution, and cytotoxicity were also discussed. Materials for surface functionalization were explored to broaden the applications and improve functionality of HoNPs. In addition, therapeutic and diagnostic applications of HoNPs were examined, comprising Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) contrast enhancement, drug delivery, and radiotherapy.

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钬纳米粒子的合成、功能化及其治疗前景综述

基于纳米颗粒的治疗剂已经成为现代医院中一种很有前途的方法，为疾病诊断和治疗提供了综合解决方案。在研究用于治疗应用的各种类型的材料中，钬纳米粒子（HoNPs）由于其优越的磁性、光学和化学性质而受到了极大的关注。因此，本文旨在探讨HoNPs的合成、功能化及其治疗前景。讨论了多元醇法、沉淀法、热分解法、溶剂热法等合成方法。纳米粒子的性质（如大小、形状和形态）、相对价值、生物分布和细胞毒性也进行了讨论。探索表面功能化材料，拓宽其应用范围，提高其功能性。此外，还研究了HoNPs的治疗和诊断应用，包括磁共振成像（MRI）和计算机断层扫描（CT）对比增强、药物输送和放射治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Results in Surfaces and Interfaces

CiteScore

2.70

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0.00%

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