Tunable luminescence of hyperbranched polysiloxanes by nonsaturation-induced electrostatic potential polarization for activatable fluorescent theranostics

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2025-05-12 DOI:10.1039/d5sc01009h

Yan Zhao, Zhixuan Feng, Miaomiao He, Xiangyi Wang, Weixu Feng, Wei Tian, Hongxia Yan

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引用次数: 0

Abstract

Developing high-efficiency luminescent polysiloxanes with activatable fluorescent theranostics is highly desirable in biomedicines. In this work, we compared hyperbranched polysiloxanes (HBPSis) with diverse nonsaturation and built an intelligent chemodynamic therapy (CDT) system with activatable fluorescence imaging. Experimental characterizations and theoretical calculations reveal that the increased nonsaturation offers numerous delocalized π electrons to renovate the polarization of electrostatic potential, which further drives the clusterization of carbonyl groups. Consequently, the through-space interactions are enhanced, leading to a red-shifted emission and improved quantum yield. Furthermore, an intelligent CDT system, HBPSi-Fe3+@AT, is fabricated. Both the CDT process and the fluorescence imaging can be activated in the presence of overexpressed glutathione. This work gains fresh insight into the nonsaturation-induced electrostatic potential polarization and presents an activatable CDT system for versatile fluorescence imaging-guided theranostics.

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非饱和诱导静电电位极化的超支化聚硅氧烷可调发光活化荧光治疗

开发具有可活化荧光治疗剂的高效发光聚硅氧烷是生物医学领域的迫切需要。在这项工作中，我们比较了不同不饱和的超支化聚硅氧烷（HBPSis），并建立了一个具有可激活荧光成像的智能化学动力学治疗（CDT）系统。实验表征和理论计算表明，非饱和的增加提供了大量的离域π电子来修复静电势的极化，从而进一步推动羰基的聚集。因此，通过空间的相互作用增强，导致红移发射和提高量子产率。在此基础上，制备了智能CDT体系HBPSi-Fe3+@AT。在谷胱甘肽过表达的情况下，CDT过程和荧光成像都可以被激活。这项工作对非饱和诱导的静电电位极化有了新的认识，并提出了一种用于多功能荧光成像引导治疗的可激活CDT系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.