Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-05-09 DOI:10.1002/eji.202451546

Emelie Backman, Remigius Gröning, Alicia Lind, Christoffer Granvik, Hinnerk Eilers, Anna Lange, Clas Ahlm, Sara Cajander, Mattias N. E. Forsell, Johan Normark, Constantin F. Urban

引用次数: 0

Abstract

Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.

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重症COVID-19男性血浆NET成分水平升高与IL-18水平升高相关

严重的COVID-19疾病伴随着高水平的血浆促炎、血栓形成前net和诱导net的细胞因子IL-18。我们发现，IL-18和NETs在患有严重疾病的男性中都升高，但在同一类别的女性中则没有升高。我们的发现为进一步研究SARS-CoV-2感染的性别相关差异提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.