The genesis of pain

IF 0.2 Q4 ANESTHESIOLOGY

Anaesthesia and Intensive Care Medicine Pub Date : 2025-05-01 DOI:10.1016/j.mpaic.2025.01.007

Mike Hudspith

引用次数: 0

Abstract

This article explores mechanisms that generate pain as a multidimensional and embodied construct rather than a simple sensory state. The shortcomings of existing models of pain will be considered alongside contemporary cognitive neuroscience theories of predictive processing, to provide a potential explanation of chronic pain states. The focus is an exploration of integrated corticothalamic-limbic processing as opposed to peripheral nociceptive mechanisms.

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疼痛的起源

本文探讨的机制，产生疼痛作为一个多维和具体化的结构，而不是一个简单的感觉状态。现有疼痛模型的缺点将与当代认知神经科学的预测处理理论一起考虑，以提供慢性疼痛状态的潜在解释。重点是综合皮质丘脑-边缘处理的探索，而不是外周伤害机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaesthesia and Intensive Care Medicine ANESTHESIOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

152

期刊介绍： Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.