Two-step upconversion-driven PDT/CDT cooperative phototherapeutic platform based on surface magnetic field modulation

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biophysical chemistry Pub Date : 2025-05-05 DOI:10.1016/j.bpc.2025.107454

Changqiu Ma , Anqi Han , Daheng Jiang , Qiuyan Wang , Linghui Zeng , Lixin Zhu , Mingya Yang , Xiaoliang Xu

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Abstract

Photodynamic therapy utilizes photosensitizer to generate reactive oxygen species (ROS) under irradiation of light for anticancer. However, due to the strong absorption of visible light by tissues and organs, photodynamic therapy meets challenges in deep tissues. Herein, we propose an upconversion-driven photodynamic therapy combined with chemodynamic therapy based on UCNP@SiO₂@Fe₃O₄@MC540. Upon the excitation of 980 nm laser, the visible emission of upconversion nanoparticles activates MC540 to produce ROS, which is enhanced by Fe₃O₄ through magnetic field modulation. Subsequently, Fe₃O₄ degrades under acidic conditions to produce ·OH via Fenton-reaction for chemodynamic therapy. The in vitro and in vivo experiments indicate that the two-step cooperative strategy exhibits significant anticancer efficacy. Besides, Finite Difference Time Domain (FDTD) simulation reveals that the enhancement stems from surface electric field and light absorption. It offers a deeper understanding of phototherapeutic process.

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基于表面磁场调制的两步上变频驱动PDT/CDT协同光疗平台

光动力疗法利用光敏剂在光照射下产生活性氧（ROS）来抗癌。然而，由于组织和器官对可见光的强烈吸收，光动力疗法在深层组织中遇到了挑战。在此，我们提出了一种基于UCNP@SiO2@Fe3O4@MC540的上转换驱动的光动力疗法结合化学动力疗法。在980 nm激光激发下，上转换纳米粒子的可见光发射激活MC540产生ROS， Fe3O4通过磁场调制增强了ROS的产生。随后，Fe3O4在酸性条件下通过fenton反应降解生成·OH进行化学动力学治疗。体外和体内实验表明，两步协同策略具有显著的抗癌效果。时域有限差分（FDTD）仿真结果表明，表面电场和光吸收是增强的主要原因。它提供了光疗过程的更深层次的理解。

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来源期刊

Biophysical chemistry 生物-生化与分子生物学

CiteScore

6.10

自引率

10.50%

发文量

121

审稿时长

20 days

期刊介绍： Biophysical Chemistry publishes original work and reviews in the areas of chemistry and physics directly impacting biological phenomena. Quantitative analysis of the properties of biological macromolecules, biologically active molecules, macromolecular assemblies and cell components in terms of kinetics, thermodynamics, spatio-temporal organization, NMR and X-ray structural biology, as well as single-molecule detection represent a major focus of the journal. Theoretical and computational treatments of biomacromolecular systems, macromolecular interactions, regulatory control and systems biology are also of interest to the journal.