John-Anthony Coppola, Dipankar Gupta, Dalia Lopez-Colon, Michael Killian, Himesh Vyas
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引用次数: 0
Abstract
Elevated arterial stiffness is associated with an increased risk of comorbidities such as stroke, heart attack, and kidney disease. Pediatric heart transplant patients are known to have arterial hypertension and elevated aortic stiffness. Limited data on pulse wave velocity (PWV), a surrogate for arterial stiffness, is available in pediatric patients. We performed an observational, prospective study assessing arterial stiffness, utilizing PWV, in pediatric heart transplant recipients. Hemodynamic tracings were obtained via pigtail catheter pullback from ascending to descending aorta during surveillance cardiac catheterization. We found that PWV was abnormal ≥4m/s in patients early and late post-heart transplantation. Cholesterol levels were negatively correlated with PWV. A serial longitudinal assessment of PWV is required to further correlate abnormal PWV with clinical complications.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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