Biogenic amines in honey bee cognition: neurochemical pathways and stress impacts

Abstract

Honey bees, as indispensable pollinators, rely on sophisticated neuromodulatory networks to regulate learning, memory, and social behaviors, all essential for colony function, ecosystem stability, and global agricultural systems. Biogenic amines octopamine, dopamine, serotonin, and tyramine are key modulators of these cognitive and behavioral processes, regulating foraging efficiency, navigational precision, and division of labor. However, we argue that anthropogenic stressors, including pesticides, pollutants, heavy metals, and microbiome dysbiosis, disrupt aminergic pathways by impairing neurotransmitter synthesis and neuronal signaling, leading to maladaptive behaviors and colony collapse. Recent discoveries expand this paradigm, revealing those biogenic amines in floral nectar act as exogenous neurochemicals, potentially altering pollinator behavior; however, their interaction with agrochemicals remains underexplored. While most studies focus on Apis mellifera, we caution that cautious extrapolation to wild and solitary bees is critical, given the evolutionary conservation of aminergic signaling across insect taxa. Cognitive deficits observed in managed honeybees likely extend to wild pollinators, threatening pollination network resilience and food security. To address these gaps, we advocate for CRISPR-based neurogenetic tools and multi-omics approaches to dissect stress susceptibility and biogenic amine (BA) regulation. Integrating neurobiology, ecotoxicology, and conservation science is imperative to develop precision strategies that mitigate anthropogenic threats, safeguard biodiversity, and stabilize global agriculture.