MEIS1: From functional versatility to post-transcriptional/translational regulation

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-05-06 DOI:10.1016/j.lfs.2025.123683

Salma A. Fahim , Shereen Ahmed El Sobky , Ahmed Abdellatif , Injie Omar Fawzy , Ahmed Ihab Abdelaziz

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引用次数: 0

Abstract

Myeloid ecotropic virus insertion site 1 (MEIS1) is a transcription factor involved in a myriad of functions such as hematopoiesis, cardiac regeneration, cell cycle progression, and limb and organ development. Its functional versatility extends beyond developmental biology, as aberrant MEIS1 expression has been implicated in various pathological contexts like carcinogenesis, cardiomyopathies, and neurodegenerative disorders. Recent advances in the field have uncovered novel layers of MEIS1 regulation, focusing on post-transcriptional and translational mechanisms, which collectively fine-tune its activity, stability, and subcellular localization. These include chromatin remodeling, epigenetic modifications in the enhancer and promoter regions, and protein modifications like phosphorylation and ubiquitination. The sophisticated regulation of MEIS1 including its interplay with non-coding RNAs (ncRNAs), either being an upstream or downstream of ncRNAs, equally represents an important regulatory mechanism orchestrating MEIS1 expression and function. This review explores the multifaceted roles of MEIS1, emphasizing its dynamic regulatory networks and their implications in physiological and pathological conditions. It also provides forward-thinking guidance on the utilization of MEIS1 in targeted therapies across various clinical settings, highlighting its potential as a key regulatory factor in disease modulation and therapeutic innovation.

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MEIS1：从功能多功能性到转录后/翻译调控

髓系嗜生态病毒插入位点1 （MEIS1）是一种转录因子，参与造血、心脏再生、细胞周期进展、肢体和器官发育等多种功能。其功能的多功能性超越了发育生物学，因为异常的MEIS1表达与各种病理背景有关，如癌变、心肌病和神经退行性疾病。该领域的最新进展揭示了MEIS1调控的新层面，重点关注转录后和翻译机制，这些机制共同微调了其活性、稳定性和亚细胞定位。这些包括染色质重塑，增强子和启动子区域的表观遗传修饰，以及磷酸化和泛素化等蛋白质修饰。MEIS1的复杂调控包括其与非编码rna （ncrna）的相互作用，无论是ncrna的上游还是下游，都同样代表了协调MEIS1表达和功能的重要调控机制。这篇综述探讨了MEIS1的多方面作用，强调其动态调控网络及其在生理和病理条件下的意义。它还为MEIS1在各种临床环境中的靶向治疗中的应用提供了前瞻性指导，突出了其作为疾病调节和治疗创新的关键调节因子的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.