Bioautography and Synthesis of Ribavirin Analogues as Possible Nucleosidase Inhibitors

Abstract

Ribavirin analogues were synthesized starting from D-glucose through a series of reactions. The structure of the synthesized compounds was confirmed by IR, NMR, and mass spectrometry. Their nucleosidase enzyme inhibitory activity was tested using TLC bioautography. Almost all of the compounds exhibited enzyme inhibitory activity.