Cyclization of Ethyl 2-[Cyano(4,6-dimethylpyrimidin-2-yl)amino]acetate

Abstract

Ethyl 2-[cyano(4,6-dimethylpyrimidin-2-yl)amino]acetate reacted with morpholine, piperidine, and acid hydrazides to give the corresponding imidazolin-4-one derivatives. Cyclization of the title compound in the presence of sulfuric acid afforded 2-iminooxazolin-5-one derivative. The latter rearranged into imidazolidine-2,4-dione by the action of potassium cyanate, and its acylation involved the imino nitrogen atom.