Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors

Abstract

The results of studying the synthesis and antiproliferative activity of new 4-(1H-benzimidazol-2-yl)­benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target com­pounds were obtained by the acylation of N-(pyrimidin-2-yl)-m-phenylenediamines with 4-(1H-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1H-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.