{"title":"A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry","authors":"Sakineh Dadashpour","doi":"10.1007/s00044-025-03390-9","DOIUrl":null,"url":null,"abstract":"<div><p>Diabetes mellitus is a chronic disorder characterized by hyperglycemia and is caused by metabolic dysregulation. According to a report from the World Health Organization (WHO), in 2014, more than 422 million people in the world were diagnosed with diabetes. In the small intestine, α-glucosidase mediates the hydrolysis of polysaccharides into monosaccharides which cause a spike in blood glucose levels. Therefore, inhibitors of α-glucosidase can reduce the rate of polysaccharides breakdown, reduce of glucose absorption, and provide antidiabetic effects. Schiff bases derived from a primary amine and carbonyl compound involving an aldehyde or a ketone, are a well-known group of organic compounds with a broad range of biological activities including antidiabetic activity. The current study emphasizes the molecular structure of various synthesized Schiff base-containing compounds and the structure-activity relationship of the most active compounds that serve as α-glucosidase inhibitors. We believe this review will provide valuable information for those developing Schiff base compounds with antidiabetic activity.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"34 5","pages":"945 - 965"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00044-025-03390-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetes mellitus is a chronic disorder characterized by hyperglycemia and is caused by metabolic dysregulation. According to a report from the World Health Organization (WHO), in 2014, more than 422 million people in the world were diagnosed with diabetes. In the small intestine, α-glucosidase mediates the hydrolysis of polysaccharides into monosaccharides which cause a spike in blood glucose levels. Therefore, inhibitors of α-glucosidase can reduce the rate of polysaccharides breakdown, reduce of glucose absorption, and provide antidiabetic effects. Schiff bases derived from a primary amine and carbonyl compound involving an aldehyde or a ketone, are a well-known group of organic compounds with a broad range of biological activities including antidiabetic activity. The current study emphasizes the molecular structure of various synthesized Schiff base-containing compounds and the structure-activity relationship of the most active compounds that serve as α-glucosidase inhibitors. We believe this review will provide valuable information for those developing Schiff base compounds with antidiabetic activity.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
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