Strategic Synthesis and Antimycobacterial Evaluation of Coumarin- and Quinoline-Substituted s-Triazine Derivatives via Palladium-Catalyzed Suzuki Coupling

Abstract

A novel and efficient synthetic pathway was devised for the preparation of 4-{4-anilino-6-[(quino­lin-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles and 4-{4-anilino-6-[(2-oxo-2H-1-benzopyran-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles via palladium-catalyzed Suzuki coupling reaction. This approach allowed precise synthesis of s-triazine derivatives. In vitro antimycobacterial testing against Mycobacterium tuberculosis H37Rv demonstrated notable efficacy, especially of the coumarin derivatives. The structural identity and purity of the products were confirmed through IR, ¹H and ¹³C NMR, and mass spectrometry.