The bidirectional interplay between gut dysbiosis and surgical complications: A systematic review

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-05-02 DOI:10.1016/j.amjsurg.2025.116369

Lindsey Nichols , Omar El-Kholy , Ahmed Adham R. Elsayed , Marc D. Basson

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引用次数: 0

Abstract

Background

The gut microbiome critically influences diverse aspects of physiology and surgical recovery. Conversely, surgery alters the microbiome, potentially predisposing to complications. We aimed to clarify the bidirectional interaction between surgery and gut dysbiosis.

Methods

On December 22nd, 2024, a systematic search of the Cochrane Library, PubMed, VHL, and WOS was completed. Relevant studies were assessed for risk of bias using STROBE and CONSORT guidelines.

Results

Thirty studies, with 2500+ participants experiencing diverse procedures and complications, were incorporated. Although specifics varied, dysbiosis correlated with surgery and its complications. Patients with complications had more harmful bacteria and fewer beneficial bacteria. In some studies, probiotics reduced complications.

Conclusion

Gut dysbiosis is tied to postoperative complications in a complex, bidirectional relationship. Patients with surgical complications may have fewer beneficial and more pathogenic bacteria both before and after surgery. Early identification of dysbiosis and probiotic administration could predict or even reduce postoperative complications.

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肠道生态失调与手术并发症之间的双向相互作用：一项系统综述

肠道微生物组对生理和手术恢复的各个方面都有重要影响。相反，手术改变了微生物群，可能导致并发症。我们的目的是阐明手术和肠道生态失调之间的双向相互作用。方法于2024年12月22日完成Cochrane Library、PubMed、VHL、WOS的系统检索。使用STROBE和CONSORT指南评估相关研究的偏倚风险。结果纳入30项研究，2500多名参与者经历了不同的手术和并发症。尽管具体情况各不相同，但生态失调与手术及其并发症相关。并发症患者有害细菌较多，有益细菌较少。在一些研究中，益生菌减少了并发症。结论肠道生态失调与术后并发症存在复杂的双向关系。手术并发症患者术前术后有益菌较少，致病菌较多。早期识别生态失调和给予益生菌可以预测甚至减少术后并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.