Choroid plexus volume and association with migraine Pathophysiology

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-05-02 DOI:10.1016/j.ejrad.2025.112135

Jianmei Xiong , Mengqi Liu , Xin Li , Zhiye Chen

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引用次数: 0

Abstract

Background

Direct evidence of choroid plexus structures involved in the presumed peripheral-central interaction in migraine is exceptionally scarce and, thus, which demands further attention.

Objectives

Our objective is to assess choroid plexus volumetric changes quantitatively in episodic and chronic migraine patients versus age and sex compared normal controls, and to elucidate the differences.

Methods

Total sixty-five participants including 18 episodic migraine patients, 16 chronic migraine patients and 31 normal controls were recruited and underwent brain MRI examinations with 3.0 T MR strength between September 2021 to May 2023. The choroid plexus of the ventricles was segmented automatically on T1-weighted MRI sequences using the FreeSurfer (Version 7.4.1) software. Lateral ventricular choroid plexus volume was normalized as the ratio of choroid plexus to ipsilateral lateral ventricle volume (CP/LV). Group differences were assessed cross-sectionally. The accuracy of CP/LV for prediction of migraine was assessed using the receiver operating characteristic curves analysis.

Results

Patients with migraine were more anxious and depressive, with heavier headache burden and impaired cognitive ability. Statistical analysis revealed group differences of the CP/LV in the right side. CP/LV ration decreased in episodic migraine patients, but the CP/LV size increased in chronic migraine patients. CP/LV of the right side was able to differentiate episodic migraine from controls with area under the ROC curve (AUC) 0.696 (95 % CI: 0.550–0.818, sensitivity 100 %, specificity 46.8 %, and the cut-off value 0.0741, P < 0.05). The diagnostic efficacy was marginally higher in distinguishing chronic migraine from episodic migraine with AUC 0.715(95 % CI: 0.536–0.856, sensitivity 50 %, specificity 94.4 % and the cut-off value 0.0725, P < 0.05).

Conclusion

Our finding suggested dynamic alteration of Lateral ventricular choroid plexus volume in the pathogenesis of migraine. The normalized CP/LV was associated with different migraine subtype. The normalized CP/LV can be used as a potential imaging biomarker for migraine diagnosis.

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脉络膜丛体积及其与偏头痛病理生理的关系

背景：脉络膜丛结构参与偏头痛外周-中枢相互作用的直接证据非常少，因此，需要进一步关注。目的：我们的目的是定量评估发作性和慢性偏头痛患者与年龄和性别相比的脉络膜丛体积变化，并阐明差异。方法在2021年9月至2023年5月期间，共招募65名参与者，包括18名发作性偏头痛患者，16名慢性偏头痛患者和31名正常对照者，接受3.0 T MR强度的脑MRI检查。使用FreeSurfer （Version 7.4.1）软件在t1加权MRI序列上自动分割脑室脉络膜丛。侧脑室脉络膜丛容积归一化为脉络膜丛与同侧侧脑室容积之比（CP/LV）。横断面评估组间差异。采用受试者工作特征曲线分析评估CP/LV预测偏头痛的准确性。结果偏头痛患者焦虑抑郁加重，头痛负担加重，认知能力受损。统计学分析显示右侧CP/LV组间差异。发作性偏头痛患者的CP/LV比值降低，而慢性偏头痛患者的CP/LV增大。右侧CP/LV能够区分发作性偏头痛与对照组，ROC曲线下面积（AUC） 0.696 (95% CI: 0.550-0.818)，敏感性100%，特异性46.8%，临界值0.0741,P <；0.05)。诊断慢性偏头痛和发作性偏头痛的疗效略高，AUC为0.715(95% CI: 0.536 ~ 0.856)，敏感性为50%，特异性为94.4%，临界值为0.0725,P <；0.05)。结论发现侧脑室脉络膜丛体积的动态改变与偏头痛的发病机制有关。标准化CP/LV与不同的偏头痛亚型相关。归一化CP/LV可作为偏头痛诊断的潜在影像学生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.