Inulin Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Levels to Inhibit Colon Tumorigenesis in Rat Models: A Systematic Review and Meta-Analysis

IF 3.2 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Food Science Pub Date : 2025-05-07 DOI:10.1111/1750-3841.70250

Yangyang Yu, Jinling He, Haiqi Fu, Yong Mi, Hao Wu, Yuan Gao, Minhui Li

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Abstract

ABSTRACT

Colorectal cancer (CRC) incidence rises with age, driven by factors such as diet. Inulin, a soluble fiber found in plants like Jerusalem artichoke and chicory, may influence CRC risk by modulating gut microbiota and improving metabolic profiles. This systematic review and meta-analysis evaluate the effects of inulin on CRC in animal models and explore its underlying mechanisms. A comprehensive search of nine databases led to the selection of 12 studies from an initial pool of 114 articles, based on predefined inclusion criteria. Standardized meta-analyses were performed for eligible studies. Results indicate that inulin supplementation significantly reduced aberrant crypt foci count in rats (SMD = −3.805, 95% CI, −7.348 to −0.262, p < 0.001), increased cecal weight (SMD = 6.723, 95% CI, 3.395–10.051, p = 0.000), enhanced colonic lactobacillus counts (SMD = 1.307, 95% CI, 0.644–1.970, p = 0.000), decreased coliform bacteria (SMD = −1.659, 95% CI, −2.147 to −1.171, p = 0.000), and elevated colonic short-chain fatty acids (SCFAs) levels, including acetate (SMD = 3.50, 95% CI, 1.111–5.890, p < 0.001), propionate (SMD = 3.081, 95% CI, 1.416–4.746, p < 0.001), and butyrate (SMD = 4.471, 95% CI, 2.464–6.478, p < 0.001). This systematic review demonstrates inulin's chemopreventive effects against CRC in animal models by enhancing beneficial gut bacteria (e.g., lactobacillus) and boosting SCFAs. Findings advocate integrating inulin-rich foods/supplements into prevention strategies for precision prebiotic development via SCFA-mediated epigenetic and antitumor mechanisms.

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菊粉调节肠道菌群和增加短链脂肪酸水平以抑制大鼠模型结肠肿瘤发生：一项系统综述和荟萃分析

结直肠癌（CRC）的发病率随着年龄的增长而上升，受饮食等因素的驱动。菊粉是一种在菊芋和菊苣等植物中发现的可溶性纤维，它可能通过调节肠道微生物群和改善代谢谱来影响结直肠癌的风险。本系统综述和荟萃分析在动物模型中评估了菊粉对结直肠癌的影响，并探讨了其潜在机制。通过对9个数据库的全面检索，根据预定义的纳入标准，从114篇文章的初始库中选择了12项研究。对符合条件的研究进行标准化荟萃分析。结果表明，添加菊粉可显著减少大鼠异常隐窝病灶计数(SMD = - 3.805, 95% CI, - 7.348 ~ - 0.262, p <；0.001)，盲肠重量增加（SMD = 6.723, 95% CI, 3.395 ~ 10.051, p = 0.000），结肠乳酸杆菌数量增加（SMD = 1.307, 95% CI, 0.644 ~ 1.970, p = 0.000），大肠菌群减少（SMD = - 1.659, 95% CI, - 2.147 ~ - 1.171, p = 0.000），结肠短链脂肪酸（SCFAs）水平升高，包括乙酸(SMD = 3.50, 95% CI, 1.111 ~ 5.890, p <；0.001)，丙酸盐(SMD = 3.081, 95% CI, 1.416-4.746, p <；0.001)，丁酸盐(SMD = 4.471, 95% CI, 2.464-6.478, p <；0.001)。本系统综述证明了菊粉在动物模型中通过增强有益肠道细菌（如乳酸菌）和促进SCFAs对结直肠癌的化学预防作用。研究结果主张通过scfa介导的表观遗传和抗肿瘤机制，将富含胰岛素的食物/补充剂纳入精准益生元开发的预防策略中。

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来源期刊

Journal of Food Science 工程技术-食品科技

CiteScore

7.10

自引率

2.60%

发文量

412

审稿时长

3.1 months

期刊介绍： The goal of the Journal of Food Science is to offer scientists, researchers, and other food professionals the opportunity to share knowledge of scientific advancements in the myriad disciplines affecting their work, through a respected peer-reviewed publication. The Journal of Food Science serves as an international forum for vital research and developments in food science. The range of topics covered in the journal include: -Concise Reviews and Hypotheses in Food Science -New Horizons in Food Research -Integrated Food Science -Food Chemistry -Food Engineering, Materials Science, and Nanotechnology -Food Microbiology and Safety -Sensory and Consumer Sciences -Health, Nutrition, and Food -Toxicology and Chemical Food Safety The Journal of Food Science publishes peer-reviewed articles that cover all aspects of food science, including safety and nutrition. Reviews should be 15 to 50 typewritten pages (including tables, figures, and references), should provide in-depth coverage of a narrowly defined topic, and should embody careful evaluation (weaknesses, strengths, explanation of discrepancies in results among similar studies) of all pertinent studies, so that insightful interpretations and conclusions can be presented. Hypothesis papers are especially appropriate in pioneering areas of research or important areas that are afflicted by scientific controversy.