Mechanochemical Synthesis of Indene-Containing Spirolactones via Tf2O-Promoted Cascade Cyclization of 2-Benzoylbenzoic Acids with Arylalkynes

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-06 DOI:10.1021/acs.orglett.5c01361

Liang Li, Zheng-Chun Yin, Xu-Ling Xia, Zhi-Ying Zhang, Guan-Wu Wang

引用次数: 0

Abstract

The Tf₂O-promoted cascade cyclization of 2-benzoylbenzoic acids with arylalkynes was achieved under solvent-free ball-milling conditions. This process renders rapid entry to the rare indene-containing spirolactones via intramolecular cyclization of 2-benzoylbenzoic acids and subsequent annulation with arylalkynes, which resulted in one C–O and two C–C bond formations. As the reactions utilize easily available starting materials and proceed in the absence of organic solvents, the present protocol constitutes an expedient and environmentally friendly access to indene-containing spirolactones.

Abstract Image

查看原文本刊更多论文

tf20催化2-苯甲酰苯甲酸与芳炔级联环化机械化学合成含吲哚内酯

在无溶剂球磨条件下，实现了tf20促进2-苯甲酰苯甲酸与芳炔的级联环化反应。该过程通过2-苯甲酰苯甲酸的分子内环化和随后与芳基炔的环化，导致一个C-O和两个C-C键的形成，从而快速进入稀有的含吲哚内酯。由于反应使用容易获得的起始材料，并且在没有有机溶剂的情况下进行，因此本议定书构成了一种方便和环保的获得含吲哚内酯的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.