Racemization of Cross-Chain Bridging Cryptands: Effects of Linker Combination on Racemization Rate

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-06 DOI:10.1021/acs.orglett.5c01161

Taisei Maruyama, Syogo Niimi, Shinobu Miyagawa, Yuji Tokunaga

引用次数: 0

Abstract

We synthesized three 28-membered chiral cross-chain bridging cryptands ([3.3.6], [4.4.5], and [5.5.4]) with three different linker combinations. After the separation of their enantiomers, the racemization behavior of the cryptands was evaluated by chiral high-performance liquid chromatography. As the number of ethylene glycol units in the two cross-chain linkages increased, the racemization reaction proceeded slowly.

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交叉链桥接密码基的外消旋：连接子组合对外消旋速率的影响

我们用三种不同的连接体组合合成了三个28元的手性交叉链桥接密码体（[3.3.6],[4.4.5]和[5.5.4]）。对映体分离后，用手性高效液相色谱法对其消旋行为进行了评价。随着两个交叉链键中乙二醇单元数的增加，外消旋反应进行缓慢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.