Emergency Department Visits due to Medication Overdose in a Finnish University Hospital

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Sami Mustajoki, Aleksi Reito, Kalle Peltonen
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引用次数: 0

Abstract

There are no recent reports from the Nordic countries describing emergency department (ED) visits due to medication overdose.

All patients visiting EDs of Tampere University Hospital, Finland, with ICD-10 codes T36–T50.9 during the year of 2021 were included in this study.

A total of 803 ED visits by 631 individual patients were identified, comprising 0.7% of all ED visits in 2021. The intention of the overdose was self-harm in 70%, inebriation in 17% and other in 13% of the visits. The mean age of the patients was 35 (range 1–95) years, and 63% were female. In 52% of the visits, the patient had taken more than one medication. Benzodiazepines were involved in 40% of the visits, followed by antipsychotics (28%), antidepressants (19%), paracetamol (15%) and opiates (13%). Twenty-six percent of the patients were admitted to the intensive care or high-dependency care unit, but there were no overdose-related in-hospital deaths. The overall 1-year mortality rate after an overdose was 2.8%.

The intention of a medication overdose was most often self-harm, followed by inebriation. Over half of the overdoses were multidrug overdoses, and psychoactive medications were predominantly used. There were no in-hospital deaths related to medication overdoses.

芬兰一所大学医院因用药过量而急诊就诊
最近没有来自北欧国家的报告描述因药物过量而就诊的急诊科(ED)。所有2021年在芬兰坦佩雷大学医院急诊科就诊且ICD-10编码为T36-T50.9的患者均纳入本研究。共有631名患者进行了803次急诊科就诊,占2021年所有急诊科就诊的0.7%。过量用药的目的是自残的占70%,醉酒的占17%,其他的占13%。患者平均年龄为35岁(1-95岁),其中63%为女性。在52%的就诊中,患者服用了一种以上的药物。苯二氮卓类药物占40%,其次是抗精神病药(28%)、抗抑郁药(19%)、扑热息痛(15%)和阿片类药物(13%)。26%的患者被送进了重症监护室或高依赖性监护室,但没有与过量用药相关的院内死亡。用药过量后1年的总死亡率为2.8%。服药过量的目的通常是自残,其次是醉酒。超过一半的过量用药是多种药物过量,主要使用精神活性药物。没有与药物过量有关的院内死亡。
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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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