Preparing the Future of Research on Deprescribing: Results From a Survey of Early Career Researchers at the 2nd International Conference on Deprescribing

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Jérôme Nguyen-Soenen, Thomas Morel, Kristie Rebecca Weir
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ECRs often face challenges, including securing funding and research grants, balancing the pressure to publish with clinical, teaching or administrative duties, limited job security, and transitioning from supervised to independent research. They can also face difficulties in establishing collaborations, building a professional network, and gaining recognition in their field [<span>4</span>].</p><p>Conferences are an avenue for collaboration, networking and reputation-building in academic communities. The first International Conference on Deprescribing (ICOD) was held in Kolding, Denmark in 2022 followed by ICOD2 in Nantes, France, in 2024. These events brought together global stakeholders, researchers, clinicians and healthcare professionals focused on deprescribing. Our research investigated ECRs' experiences within this community. Our purpose was to characterize the ECRs, the challenges they face, and their insights on the development of a group to support them.</p><p>We defined ECR as ‘students or within 5 years of obtaining their PhD or highest degree, not including breaks for part-time work, parental leave, clinical training or health reasons’. Participants of ICOD2 were asked to identify as an ECR when they registered. We distributed an online survey via email on 20 September 2024, with participants having until the start of the conference on 24 September 2024, to submit their responses. Preliminary survey results were presented at an ICOD2 ECR seminar and networking event at the conference.</p><p>LimeSurvey (LimeSurvey GmbH, 2023) was used to create the questionnaire. The survey contained 13 questions on demographics, research focus, conference participation, future directions and feedback (Data S1). Future directions included questions on career aspirations, challenges faced and the possible formation of an ECR group. The feedback questions focused on topics of interest at the conference and how the conference could provide support for ECR. The questions were designed by the authors in collaboration with two experts in deprescribing research. The responses were multiple choice, free text or ‘Yes/No’. Responses were anonymous and confidential, and participation was voluntary.</p><p>A descriptive analysis was conducted using Excel (Microsoft Corporation, 2021). We defined participants who had a healthcare profession as ‘clinician researchers’. We defined participants who did not declare a healthcare profession as ‘nonclinician researchers’. We compared clinician researchers with nonclinician researchers to identify differences in their research experiences using the Fisher test. A <i>p</i>-value &lt; 0.05 was considered statistically significant. This study received a waiver from the ethics committee of the Canton of Bern, Switzerland.</p><p>There was a total of 186 registrants for ICOD2. The survey was sent to 52 (28.0%) registrants who identified as an ECR. We received responses from 47 (90.4%) participants from 14 countries across three continents. Respondent characteristics are shown in Table 1. Six different academic titles were represented, with the most common being PhD student (19, 40.4%). Four healthcare professions were represented: pharmacists (15, 31.9%), medical doctors (8, 17.0%), advanced practice nurses (2, 4.3%) and a nurse (1, 2.1%). We identified 26 (55.3%) clinician researchers and 21 (44.7%) nonclinician researchers. The primary research focus of ECRs were patient outcomes (25, 53.2%), medication safety (23, 48.9%), clinical practice (21, 44.7%) and behavioural science or implementation (19, 40.4%). Older adults were the most targeted population group (31, 66.0%). More than a half of the ECRs were attending ICOD for the first time (25, 53.2%), and most were presenting in some form at the conference (34, 72.3%).</p><p>The primary motivations of ECRs for attending the conference were to learn about new research and to network (Table 2). The vast majority of ECRs aspired to pursue a career in academia (38, 80.9%). The main challenges ECRs faced in deprescribing research were time constraints (20, 42.6%), funding (18, 38.3%) and access to data (15, 31.9%).</p><p>Both clinician and nonclinician researchers identified challenges in deprescribing research, including funding (42.3% vs. 33.3%, respectively, <i>p</i> = 0.877) and access to data (34.6% vs. 33.3%, respectively, <i>p</i> = 1.000). However, clinician researchers were significantly more likely to report time constraints as a barrier compared with nonclinician researchers (61.5% vs. 28.6%, <i>p</i> = 0.044) (Figure 1).</p><p>Over 75% (<i>n</i> = 36) of ECRs were interested in being involved in an ECR deprescribing research group (Table 3). Participants provided free-text responses regarding the purpose of the group, with nine (25.0%) wanting to collaborate and network. Regarding the meeting structures, 11 (30.6%) preferred a journal club format and 10 (27.8%) wanted meetings every 3 to 4 months. At the conference, preliminary survey findings were presented at an ECR seminar and networking event with approximately 20 ECRs in attendance. We had discussions about current funding opportunities for ECRs through the deprescribing networks, we identified shared research interests of the ECRs and encouraged collaborations between individuals, groups and countries.</p><p>Our survey received responses from 47 ECRs (90%) from 14 countries who were attending ICOD2. While most ECRs aimed for academic careers, they reported challenges, particularly time constraints for clinician researchers, alongside funding and data access issues. ECRs focused their research on patient outcomes, medication safety, and clinical practice, with older adults as a key population, reflecting some of the global priorities in deprescribing research [<span>5</span>].</p><p>Conferences serve as a useful platform for ECRs to build professional networks and to develop their research and interpersonal skills [<span>6</span>]. Effective strategies to support ECR career development and advancement were embedded throughout the ICOD2 conference structure, serving as an example. The Scientific and Organizing Committees deliberately integrated ECRs into key roles, including committee membership (50%), plenary presentations (with ECR speakers in every session), and session chair positions (30%), and ECR-specific presentation awards. The strategy proved successful, with ECRs comprising 72% of presenters and showing strong engagement through a 90% survey response rate. ICOD2's approach demonstrates how conferences can create meaningful advancement opportunities by actively incorporating ECRs into all aspects of scientific programming and leadership. The high interest in forming an international research group for ECRs shows they are seeking networking and ongoing engagement within the field.</p><p>Most ECRs aspire to careers in academia (80.9%), which could reflect the need for sustainable academic pathways and long-term support for researchers in the early stage. The key challenges of time constraints, funding and access to data faced by ECRs are common in academia [<span>7, 8</span>], but may be particularly significant in emerging fields like deprescribing. Potential solutions may be mentorship programs or collaborative funding initiatives [<span>9, 10</span>]. Limited funding and data access may ultimately hinder innovation and advancements in deprescribing research. Institutions and funding bodies could better support ECRs by creating targeted grants for pilot funding or travel awards.</p><p>Our study had several limitations. The ECRs included in our study were delegates of ICOD2, and we did not survey ECRs outside this conference. It is possible that ECRs attending an international conference may be more supported or have access to greater funding than those unable to attend—meaning we might have underestimated issues faced by ECRs in our survey. However, it was a pragmatic recruitment strategy and the high-level response rate permitted us to draw some conclusions. Also, participants self-reported their ECR status that may have led to a declaration bias. Our survey did not capture how time is allocated across research, clinical, teaching and administrative roles, highlighting the need for future studies to better characterize role distribution among both clinician and nonclinician researchers. A strength was the diverse geographical locations and professional disciplines represented by the participating ECRs.</p><p>This survey highlights the experiences of ECRs in deprescribing research, with the conference providing a practical and pragmatic setting for data collection. Future research could incorporate qualitative or mixed methods approaches for deeper insights. Our findings provide a foundation for shaping future ECR surveys, meetings and initiatives both as part of this conference and more broadly.</p><p>J.N.S., T.M. and K.R.W. were involved in the conception of the study. J.N.S., T.M. and K.R.W. were involved in the data collection. J.N.S., T.M. and K.R.W. were involved in the data analysis. J.N.S., T.M. and K.R.W. were involved in the data interpretation. J.N.S. and K.R.W. drafted the first version of the manuscript. J.N.S., T.M. and K.R.W. read and approved the final manuscript. J.N.S. can be contacted for access to the dataset underlying the current analysis.</p><p>This study received a waiver from the ethics committee of the Canton of Bern, Switzerland.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":8733,"journal":{"name":"Basic & Clinical Pharmacology & Toxicology","volume":"136 6","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/bcpt.70049","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic & Clinical Pharmacology & Toxicology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/bcpt.70049","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
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Abstract

Deprescribing is an expanding area of research with the term first coined in the scientific literature by Woodward in 2003 [1] and was defined by consensus by Reeve et al. in 2015 [2]. Consequently, the growing community of deprescribing researchers has led to an increasing number of students and a rise in early career researchers (ECRs) in the field.

An ECR is generally defined as someone within the first 5 years of academic or research-related employment following the completion of their postgraduate training, with a focus on stable research development [3]. ECRs often face challenges, including securing funding and research grants, balancing the pressure to publish with clinical, teaching or administrative duties, limited job security, and transitioning from supervised to independent research. They can also face difficulties in establishing collaborations, building a professional network, and gaining recognition in their field [4].

Conferences are an avenue for collaboration, networking and reputation-building in academic communities. The first International Conference on Deprescribing (ICOD) was held in Kolding, Denmark in 2022 followed by ICOD2 in Nantes, France, in 2024. These events brought together global stakeholders, researchers, clinicians and healthcare professionals focused on deprescribing. Our research investigated ECRs' experiences within this community. Our purpose was to characterize the ECRs, the challenges they face, and their insights on the development of a group to support them.

We defined ECR as ‘students or within 5 years of obtaining their PhD or highest degree, not including breaks for part-time work, parental leave, clinical training or health reasons’. Participants of ICOD2 were asked to identify as an ECR when they registered. We distributed an online survey via email on 20 September 2024, with participants having until the start of the conference on 24 September 2024, to submit their responses. Preliminary survey results were presented at an ICOD2 ECR seminar and networking event at the conference.

LimeSurvey (LimeSurvey GmbH, 2023) was used to create the questionnaire. The survey contained 13 questions on demographics, research focus, conference participation, future directions and feedback (Data S1). Future directions included questions on career aspirations, challenges faced and the possible formation of an ECR group. The feedback questions focused on topics of interest at the conference and how the conference could provide support for ECR. The questions were designed by the authors in collaboration with two experts in deprescribing research. The responses were multiple choice, free text or ‘Yes/No’. Responses were anonymous and confidential, and participation was voluntary.

A descriptive analysis was conducted using Excel (Microsoft Corporation, 2021). We defined participants who had a healthcare profession as ‘clinician researchers’. We defined participants who did not declare a healthcare profession as ‘nonclinician researchers’. We compared clinician researchers with nonclinician researchers to identify differences in their research experiences using the Fisher test. A p-value < 0.05 was considered statistically significant. This study received a waiver from the ethics committee of the Canton of Bern, Switzerland.

There was a total of 186 registrants for ICOD2. The survey was sent to 52 (28.0%) registrants who identified as an ECR. We received responses from 47 (90.4%) participants from 14 countries across three continents. Respondent characteristics are shown in Table 1. Six different academic titles were represented, with the most common being PhD student (19, 40.4%). Four healthcare professions were represented: pharmacists (15, 31.9%), medical doctors (8, 17.0%), advanced practice nurses (2, 4.3%) and a nurse (1, 2.1%). We identified 26 (55.3%) clinician researchers and 21 (44.7%) nonclinician researchers. The primary research focus of ECRs were patient outcomes (25, 53.2%), medication safety (23, 48.9%), clinical practice (21, 44.7%) and behavioural science or implementation (19, 40.4%). Older adults were the most targeted population group (31, 66.0%). More than a half of the ECRs were attending ICOD for the first time (25, 53.2%), and most were presenting in some form at the conference (34, 72.3%).

The primary motivations of ECRs for attending the conference were to learn about new research and to network (Table 2). The vast majority of ECRs aspired to pursue a career in academia (38, 80.9%). The main challenges ECRs faced in deprescribing research were time constraints (20, 42.6%), funding (18, 38.3%) and access to data (15, 31.9%).

Both clinician and nonclinician researchers identified challenges in deprescribing research, including funding (42.3% vs. 33.3%, respectively, p = 0.877) and access to data (34.6% vs. 33.3%, respectively, p = 1.000). However, clinician researchers were significantly more likely to report time constraints as a barrier compared with nonclinician researchers (61.5% vs. 28.6%, p = 0.044) (Figure 1).

Over 75% (n = 36) of ECRs were interested in being involved in an ECR deprescribing research group (Table 3). Participants provided free-text responses regarding the purpose of the group, with nine (25.0%) wanting to collaborate and network. Regarding the meeting structures, 11 (30.6%) preferred a journal club format and 10 (27.8%) wanted meetings every 3 to 4 months. At the conference, preliminary survey findings were presented at an ECR seminar and networking event with approximately 20 ECRs in attendance. We had discussions about current funding opportunities for ECRs through the deprescribing networks, we identified shared research interests of the ECRs and encouraged collaborations between individuals, groups and countries.

Our survey received responses from 47 ECRs (90%) from 14 countries who were attending ICOD2. While most ECRs aimed for academic careers, they reported challenges, particularly time constraints for clinician researchers, alongside funding and data access issues. ECRs focused their research on patient outcomes, medication safety, and clinical practice, with older adults as a key population, reflecting some of the global priorities in deprescribing research [5].

Conferences serve as a useful platform for ECRs to build professional networks and to develop their research and interpersonal skills [6]. Effective strategies to support ECR career development and advancement were embedded throughout the ICOD2 conference structure, serving as an example. The Scientific and Organizing Committees deliberately integrated ECRs into key roles, including committee membership (50%), plenary presentations (with ECR speakers in every session), and session chair positions (30%), and ECR-specific presentation awards. The strategy proved successful, with ECRs comprising 72% of presenters and showing strong engagement through a 90% survey response rate. ICOD2's approach demonstrates how conferences can create meaningful advancement opportunities by actively incorporating ECRs into all aspects of scientific programming and leadership. The high interest in forming an international research group for ECRs shows they are seeking networking and ongoing engagement within the field.

Most ECRs aspire to careers in academia (80.9%), which could reflect the need for sustainable academic pathways and long-term support for researchers in the early stage. The key challenges of time constraints, funding and access to data faced by ECRs are common in academia [7, 8], but may be particularly significant in emerging fields like deprescribing. Potential solutions may be mentorship programs or collaborative funding initiatives [9, 10]. Limited funding and data access may ultimately hinder innovation and advancements in deprescribing research. Institutions and funding bodies could better support ECRs by creating targeted grants for pilot funding or travel awards.

Our study had several limitations. The ECRs included in our study were delegates of ICOD2, and we did not survey ECRs outside this conference. It is possible that ECRs attending an international conference may be more supported or have access to greater funding than those unable to attend—meaning we might have underestimated issues faced by ECRs in our survey. However, it was a pragmatic recruitment strategy and the high-level response rate permitted us to draw some conclusions. Also, participants self-reported their ECR status that may have led to a declaration bias. Our survey did not capture how time is allocated across research, clinical, teaching and administrative roles, highlighting the need for future studies to better characterize role distribution among both clinician and nonclinician researchers. A strength was the diverse geographical locations and professional disciplines represented by the participating ECRs.

This survey highlights the experiences of ECRs in deprescribing research, with the conference providing a practical and pragmatic setting for data collection. Future research could incorporate qualitative or mixed methods approaches for deeper insights. Our findings provide a foundation for shaping future ECR surveys, meetings and initiatives both as part of this conference and more broadly.

J.N.S., T.M. and K.R.W. were involved in the conception of the study. J.N.S., T.M. and K.R.W. were involved in the data collection. J.N.S., T.M. and K.R.W. were involved in the data analysis. J.N.S., T.M. and K.R.W. were involved in the data interpretation. J.N.S. and K.R.W. drafted the first version of the manuscript. J.N.S., T.M. and K.R.W. read and approved the final manuscript. J.N.S. can be contacted for access to the dataset underlying the current analysis.

This study received a waiver from the ethics committee of the Canton of Bern, Switzerland.

The authors declare no conflicts of interest.

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为处方化研究的未来做准备:来自第二届国际处方化会议早期职业研究者的调查结果
处方化是一个不断扩大的研究领域,该术语最早由Woodward于2003年在科学文献中提出,并由Reeve等人于2015年一致定义。因此,不断增长的处方研究人员群体导致了该领域学生数量的增加和早期职业研究人员(ecr)的增加。ECR一般被定义为在完成研究生培训后的前5年内从事学术或研究相关工作的人,重点是稳定的研究发展bb0。ecr经常面临挑战,包括获得资金和研究资助,平衡出版压力与临床、教学或行政职责,有限的工作保障,以及从监督研究过渡到独立研究。他们也可能在建立合作、建立专业网络和在自己的领域获得认可方面面临困难。会议是学术界合作、建立网络和建立声誉的途径。第一届国际处方减少会议(ICOD)于2022年在丹麦科灵举行,第二届ICOD会议于2024年在法国南特举行。这些活动汇集了全球利益攸关方、研究人员、临床医生和专注于开处方的卫生保健专业人员。我们的研究调查了ecr在这个社区中的经历。我们的目的是描述ecr,他们面临的挑战,以及他们对支持他们的团队发展的见解。我们将ECR定义为“学生或获得博士学位或最高学位后的5年内,不包括兼职工作、育儿假、临床培训或健康原因的休息时间”。ICOD2的参与者在注册时被要求确认为ECR。我们于2024年9月20日通过电子邮件分发了一份在线调查,参与者必须在2024年9月24日会议开始之前提交他们的回答。初步调查结果在会议的ICOD2 ECR研讨会和网络活动上公布。limessurvey (limessurvey GmbH, 2023)被用来制作问卷。调查包含13个问题,涉及人口统计、研究重点、会议参与、未来方向和反馈(数据S1)。未来的方向包括关于职业抱负、面临的挑战和可能组建ECR小组的问题。反馈问题集中在会议感兴趣的主题上,以及会议如何为ECR提供支持。这些问题是作者与两位解题研究专家合作设计的。回答是多项选择、自由文本或“是/否”。回答是匿名和保密的,参与是自愿的。使用Excel (Microsoft Corporation, 2021)进行描述性分析。我们将从事医疗保健职业的参与者定义为“临床研究人员”。我们将未宣布从事医疗保健职业的参与者定义为“非临床研究人员”。我们比较了临床研究人员和非临床研究人员,以确定他们的研究经验的差异使用费舍尔测试。p值&lt; 0.05被认为具有统计学意义。本研究获得了瑞士伯尔尼州伦理委员会的豁免。ICOD2的注册人共有186人。该调查被发送给52名(28.0%)确认为ECR的注册人。我们收到了来自三大洲14个国家的47位参与者(90.4%)的回复。受访者特征如表1所示。有6种不同的学术头衔,最常见的是博士生(19.40.4%)。代表了四种医疗保健专业:药剂师(15.31.9%)、医生(8.17.0%)、高级执业护士(2.4.3%)和护士(1.2.1%)。我们确定了26名(55.3%)临床研究人员和21名(44.7%)非临床研究人员。ecr的主要研究重点是患者结局(25,53.2%)、用药安全性(23,48.9%)、临床实践(21,44.7%)和行为科学或实施(19,40.4%)。老年人是最主要的目标人群(31.66.0%)。超过一半的ecr是第一次参加ICOD(25.53.2%),大多数ecr以某种形式参加了会议(34.72.3%)。ecr参加会议的主要动机是了解新的研究和建立网络(表2)。绝大多数ecr希望在学术界从事职业(38,80.9%)。ecr在研究处方化方面面临的主要挑战是时间限制(20.42.6%)、资金支持(18.38.3%)和数据获取(15.31.9%)。临床医生和非临床医生研究人员都发现了在处方化研究方面的挑战,包括资金(分别为42.3%对33.3%,p = 0.877)和数据获取(分别为34.6%对33.3%,p = 1.000)。 然而,与非临床研究人员相比,临床研究人员更有可能报告时间限制是一个障碍(61.5%比28.6%,p = 0.044)(图1)。超过75% (n = 36)的ECR有兴趣参与ECR处方研究小组(表3)。参与者提供了关于小组目的的自由文本回复,其中9人(25.0%)想要合作和建立网络。在会议结构方面,11人(30.6%)更喜欢期刊俱乐部的形式,10人(27.8%)希望每3到4个月举行一次会议。在会议上,初步调查结果在ECR研讨会和网络活动上公布,约有20名ECR出席。我们通过处方网络讨论了目前ecr的资助机会,我们确定了ecr的共同研究兴趣,并鼓励个人、团体和国家之间的合作。我们的调查收到了来自14个国家参加ICOD2的47名ecr(90%)的回复。虽然大多数ecr的目标是学术生涯,但他们报告了挑战,特别是临床研究人员的时间限制,以及资金和数据访问问题。ecr将研究重点放在患者预后、药物安全性和临床实践上,并将老年人作为关键人群,这反映了全球在处方研究方面的一些优先事项。会议为环境研究人员提供了一个建立专业网络、发展研究和人际交往能力的有用平台。作为一个例子,支持ECR职业发展和晋升的有效战略贯穿于ICOD2会议结构中。科学委员会和组织委员会有意将ECR纳入关键角色,包括委员会成员(50%),全体会议发言(每次会议都有ECR发言人),会议主席职位(30%),以及ECR特定的演讲奖。事实证明,这一策略是成功的,演讲者中有72%是ecr, 90%的调查回复率显示出了强烈的参与度。ICOD2的方法展示了会议如何通过积极地将ecr纳入科学规划和领导的各个方面来创造有意义的进步机会。对组建ecr国际研究小组的高度兴趣表明,他们正在寻求在该领域建立网络和持续参与。大多数ecr渴望在学术界工作(80.9%),这可以反映出在早期阶段需要可持续的学术途径和对研究人员的长期支持。ecr面临的时间限制、资金和数据获取等关键挑战在学术界很常见[7,8],但在处方开具等新兴领域可能尤为重要。潜在的解决方案可能是指导计划或合作资助计划[9,10]。有限的资金和数据获取可能最终阻碍描述研究的创新和进步。机构和资助机构可以通过设立试点资金或旅行奖励的定向赠款来更好地支持生态环境研究。我们的研究有几个局限性。纳入我们研究的ecr是ICOD2的代表,我们没有调查本次会议之外的ecr。参加国际会议的ecr可能比那些不能参加会议的ecr得到更多的支持或获得更多的资金——这意味着我们可能低估了ecr在调查中面临的问题。然而,这是一个务实的招聘策略,高水平的回应率使我们能够得出一些结论。此外,参与者自我报告了他们的ECR状态,这可能导致声明偏差。我们的调查没有捕捉到时间是如何在研究、临床、教学和管理角色之间分配的,这突出了未来研究的需要,以更好地表征临床和非临床研究人员之间的角色分配。一个优势是参与的环境研究小组所代表的地理位置和专业学科不同。本次调查突出了ecr在描述研究方面的经验,会议为数据收集提供了一个实际和务实的环境。未来的研究可以结合定性或混合方法,以获得更深入的见解。我们的研究结果为塑造未来的ECR调查、会议和倡议提供了基础,这些调查、会议和倡议都是本次会议的一部分,而且范围更广。T.M.和K.R.W.都参与了这项研究的构思。j.n.s., T.M.和K.R.W.参与了数据收集。j.n.s., T.M.和K.R.W.参与了数据分析。j.n.s., T.M.和K.R.W.参与了数据解释。J.N.S.和K.R.W.起草了手稿的第一版。j.n.s., T.M.和K.R.W.阅读并批准了最后的手稿。可以联系J.N.S.访问当前分析的数据集。本研究获得了瑞士伯尔尼州伦理委员会的豁免。 作者声明无利益冲突。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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